Publications by authors named "J A Dye"
Maternal exposure to ozone during implantation results in reduced fetal weight gain in rats. Offspring from ozone-exposed dams demonstrate sexually dimorphic risks to high-fat diet feeding in adolescence. To better understand the adolescent hepatic metabolic landscape following fetal growth restriction, RNA sequencing was performed to characterize the effects of ozone-induced fetal growth restriction on male and female offspring.
View Article and Find Full Text PDFmRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate enabling positron emission tomography (PET) tracer labeling of LNP/mRNA vaccines for quantitative visualization of vaccine trafficking in live mice and non-human primates (NHPs). Following intramuscular injection, we observed LNPs distributing through injected muscle tissue, simultaneous with rapid trafficking to draining lymph nodes (dLNs).
View Article and Find Full Text PDFThe Ebola virus (EBOV) causes severe disease in humans, and animal models are needed to evaluate the efficacy of vaccines and therapeutics. While non-human primate (NHP) and rodent EBOV infection models have been well characterized, there is a growing need for an intermediate model. Here, we provide the first report of a small-particle aerosol (AE) EBOV ferret model and disease progression compared with the intramuscular (IM) EBOV ferret model.
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- The study evaluated how well four generative AI models (Perplexity, ChatGPT 4o, Microsoft Copilot, and Google Gemini) answered questions based on the 2023 CNS guidelines for Chiari 1 malformation, categorizing their responses as "concordant" or "non-concordant."
- Perplexity had the highest concordance rate at 69.2%, while ChatGPT had the lowest at 23.1%. All AI models had issues with over-conclusive answers and varying degrees of insufficient responses.
- Readability tests indicated all models produced complex and challenging responses, highlighting the need for caution in using AI for clinical decision-making due to their low alignment with established medical
Introduction: Pectoralis Minor (PM) length shortening may contribute to faulty scapular. kinematics and result in shoulder pathology.
Purpose: of the Study: To evaluate if a prone scapular retraction exercise will demonstrate an immediate lengthening of the pectoralis minor (PM) in healthy participants.