Publications by authors named "J A Dunlop"

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation of p38 mitogen-activated protein kinase (MAPK) is implicated in ALS.

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  • Scorpions have a long evolutionary history with a complex classification system that has evolved over time, starting from early divisions based on leg structures in 1884.
  • Various researchers contributed to the classification, utilizing different morphological features like mesosomal sclerites and tergites to categorize scorpions into distinct groups over the years.
  • Currently, there are 43 known extinct families and 24 living families of scorpions, with some of the living families having fossil representatives, indicating a diverse lineage that goes back to the Triassic period.
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  • Cardiovascular disease is the top cause of death for dialysis patients, often linked to fluid overload and high blood pressure, suggesting that lower sodium levels in dialysis might help reduce these issues.
  • This review aims to assess the pros and cons of using low dialysate sodium concentrations (<138 mM) for patients undergoing maintenance hemodialysis.
  • Out of the 17 studies included, which involved 509 patients, most focused on fixed low sodium concentrations, with data analyzed to evaluate the effectiveness and safety of this treatment.
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