Publications by authors named "J A Dodge"
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often analyzed in tissue, but this approach fails to resolve cell-type differences in ceramide homeostasis that are likely essential to understanding cell and non-cell autonomous contributions to neurodegeneration.
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- Acamprosate is a treatment for people with alcohol problems, but we don't know much about how safe it is for those who have had a liver transplant.
- In a study with 30 participants, some took acamprosate and others received standard care over 14 weeks, looking at side effects and how well the treatment worked.
- The results showed that acamprosate seemed safe and worked just as well as standard care, which is good news for future research on helping liver transplant patients with alcohol issues.
Article Synopsis
- Emergency departments (EDs) are facing increased costs and congestion, and this study focuses on the under-researched impact of ED visits for patients with cirrhosis compared to those without liver issues.
- The analysis was conducted on over 38 million patients from a database, showing that those with cirrhosis had significantly higher ED visits and 90-day mortality rates than patients without cirrhosis and those with other chronic conditions like congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD).
- Results indicated that non-liver-related ED visits were more likely to result in patients being discharged home, and those without outpatient follow-up after an ED visit experienced higher mortality rates, highlighting the need for better