Publications by authors named "J A Deprest"
Background: General anesthesia during pregnancy is not uncommon, for example, for trauma surgery, cerclage, or cesarean delivery. Current recommendations are to maintain maternal partial pressure of carbon dioxide in arterial blood (paCO2) at 30 mm Hg, which is based solely on the average maternal paCO2 in awake pregnant women. However, there is no evidence that this target, compared to other targets, would enable optimal conditions for the fetus during general anesthesia.
View Article and Find Full Text PDFObjective: We examined the role of myofibroblasts in regulating Cx43 and collagen structure in iatrogenic preterm amniotic membrane (AM) defects subjected to mechanical stimulation.
Method: Preterm AM specimens were collected from women undergoing planned preterm caesarean section after in utero intervention for correction of spina bifida by open fetal surgery (n = 4 patients; preterm delivery at 34 + 0 weeks to 35 + 0 weeks). Control specimens taken 5 cm away from the open fetal surgery defect site were compared with wound edge AM.
Article Synopsis
- The study aimed to compare the effectiveness of Er:YAG laser treatment and pelvic floor exercises (PFE) in improving symptoms of mild to moderate pelvic organ prolapse in women.
- A randomized controlled trial with 46 participants showed that both treatments led to significant symptom improvement after four months, with no serious adverse events reported.
- While laser therapy appeared slightly more effective than PFE at four months, both treatments yielded similar overall results and neither produced lasting effects by the 24-month follow-up.
The aim of this pragmatic approach to retrospective observational study was to identify the end-tidal concentration of sevoflurane which was associated with optimal surgical conditions (i.e., absence of any movement, coughing and straining) in 127 pregnant sheep.
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