Publications by authors named "J A Darr"

Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs), which influences offspring development and adult phenotypes. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood. Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health.

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A novel eco-friendly high throughput continuous hydrothermal flow system was used to synthesise phase pure ZnO and doped ZnO in order to explore their properties for tissue engineering applications. Cerium, zirconium, and copper were introduced as dopants during flow synthesis of ZnO nanoparticles, Zirconium doped ZnO were successfully synthesised, however secondary phases of CeO and CuO were detected in X-ray diffraction (XRD). The nanoparticles were characterised using X-ray diffraction, Brunauer-Emmett-Teller (BET), Dynamic Light scattering Measurements, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and RAMAN spectroscopy was used to evaluate physical, chemical, and structural properties.

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Article Synopsis
  • Updated guidelines revise the 2014 recommendations for managing atopic dermatitis (AD) using phototherapy and systemic therapies.
  • A multidisciplinary team systematically reviewed evidence and used the GRADE approach to create 11 recommendations for adult AD management.
  • Strong support was found for biologic and immunomodulatory treatments like dupilumab and abrocitinib, while phototherapy and certain medications received conditional support, and systemic corticosteroids were not recommended.
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Article Synopsis
  • The text discusses updated guidelines for treating atopic dermatitis (AD) in adults, particularly using phototherapy and systemic therapies since multiple new treatments were approved after 2014.* -
  • A multidisciplinary workgroup established 11 evidence-based recommendations, emphasizing strong support for biologics and oral JAK inhibitors, while recommending caution with systemic corticosteroids.* -
  • Limitations in the review highlight that many trials are short-term, which hampers the assessment of long-term effectiveness and safety for these treatments.*
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The development of oxidation catalysts that are resistant to sulfur poisoning is crucial for extending the lifespan of catalysts in real-working conditions. Herein, we describe the design and synthesis of oxide-metal interaction (OMI) catalyst under oxidative atmospheres. By using organic coated TiO , an oxide/metal inverse catalyst with non-classical oxygen-saturated TiO overlayers were obtained at relatively low temperature.

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