In Silico Identification of Potential Clovibactin-like Antibiotics Binding to Unique Cell Wall Precursors in Diverse Gram-Positive Bacterial Strains.

The rise in multidrug-resistant bacteria highlights the critical need for novel antibiotics. This study explores clovibactin-like compounds as potential therapeutic agents targeting lipid II, a crucial component in bacterial cell wall synthesis, using in silico techniques. A total of 2624 clovibactin analogs were sourced from the PubChem database and screened using ProTox 3.

The incidence and severe consequences of occupational injuries among informal workers in a developing country.

This article uses novel microdata to estimate the prevalence of occupational injuries among informal workers in a developing country with a segmented labour market like Argentina, and analyses their socio-economic consequences, exploring the heterogeneity according to the formality status of the worker. The results indicate that the prevalence of injuries is roughly similar between informal and formal workers. However, the socio-economic consequences are substantially more severe for informal workers and their families.

Using computer modeling to find new LRRK2 inhibitors for parkinson's disease.

Parkinson's disease (PD) is a complex neurodegenerative disorder that affects multiple neurotransmitters, and its exact cause is still unknown. Developing new drugs for PD is a lengthy and expensive process, making it difficult to find new treatments. This study aims to create a detailed dataset to build strong predictive models with various machine learning algorithms.

Fluorescence polarization assays to study carbohydrate-protein interactions.

Fluorescence polarization (FP) is a useful technique to study the interactions between carbohydrates and proteins in solution, by using standard equipment and minimal sample consumption. Here, we will review the most recent FP-based approaches in this field, including the study of carbohydrate-lectin, carbohydrate-enzyme and glycosaminoglycan-protein interactions. Advantages and limitations of this methodology will be discussed.

Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study.

The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and Alzheimer's disease. The potential of various compounds as AChE inhibitors was investigated.