Publications by authors named "J A D'Agostino"
Regurgitation and reingestion (R/R) and coprophagy are common behaviors exhibited by primates living in human care. To reduce this undesirable behavior in two troops of western lowland gorillas (Gorilla gorilla gorilla), the diet was modified by increasing fiber (by increasing browse) and decreasing starch (by reducing but not eliminating biscuits). We monitored behavior before, 3 weeks after, and 1 year after the diet change.
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- * A study involving 138 cognitively unimpaired adults investigated how myelin content impacts gait speed over approximately 6.42 years, using advanced imaging techniques to assess myelin levels and standard protocols for measuring usual and rapid gait speeds.
- * Results indicate that lower myelin content is associated with a notable decline in usual gait speed, particularly in brain areas related to motor planning, suggesting that monitoring gait speed could help identify neurodegeneration in otherwise healthy individuals.
Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's diseases. Thus, improving myelin integrity may be an effective intervention to prevent and treat age-associated neurodegenerative pathologies. It has been suggested that cardiorespiratory fitness (CRF) may preserve and enhance cerebral myelination throughout the adult lifespan, but this hypothesis has not been fully tested.
View Article and Find Full Text PDFImportance: Neurodevelopmental outcomes for children with congenital heart defects (CHD) have improved minimally over the past 20 years.
Objectives: To assess the feasibility and tolerability of maternal progesterone therapy as well as the magnitude of the effect on neurodevelopment for fetuses with CHD.
Design, Setting, And Participants: This double-blinded individually randomized parallel-group clinical trial of vaginal natural progesterone therapy vs placebo in participants carrying fetuses with CHD was conducted between July 2014 and November 2021 at a quaternary care children's hospital.
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- The study focused on evaluating the correlation and concordance between different activity score indices for Polymyalgia Rheumatica (PMR), particularly including the C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS).
- Data were analyzed from the SEMAPHORE trial, comparing the efficacy of tocilizumab to placebo in PMR patients while measuring various PMR-ASs at multiple visits.
- Results showed an excellent correlation between the activity scores, indicating that in trials with drugs affecting CRP levels, these derived scores can be reliably used.