Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON).

Traumatic optic neuropathy (TON) has been regarded a vision-threatening condition caused by either ocular or blunt/penetrating head trauma, which is characterized by direct or indirect TON. Injury happens during sports, vehicle accidents and mainly in military war and combat exposure. Earlier, we have demonstrated that remote ischemic post-conditioning (RIC) therapy is protective in TON, and here we report that AMPKα1 activation is crucial.

SEN2NAIP: A large-scale dataset for Sentinel-2 Image Super-Resolution.

The increasing demand for high spatial resolution in remote sensing has underscored the need for super-resolution (SR) algorithms that can upscale low-resolution (LR) images to high-resolution (HR) ones. To address this, we present SEN2NAIP, a novel and extensive dataset explicitly developed to support SR model training. SEN2NAIP comprises two main components.

Sensor-measured versus reported latrine use to characterize sanitation intervention uptake in a randomized controlled trial among households in rural Bangladesh.

Sanitation programs typically measure latrine access, which does not equate to use. We aimed to objectively measure latrine use with sensors among households enrolled in the sanitation and control groups of a randomized controlled trial (WASH Benefits) in Bangladesh. The intervention provided upgraded latrines and behavioral promotion.

Endomicroscopic AI-driven morphochemical imaging and fs-laser ablation for selective tumor identification and selective tissue removal.

The rising incidence of head and neck cancer represents a serious global health challenge, requiring more accurate diagnosis and innovative surgical approaches. Multimodal nonlinear optical microscopy, combining coherent anti-Stokes Raman scattering (CARS), two-photon excited fluorescence (TPEF), and second-harmonic generation (SHG) with deep learning-based analysis routines, offers label-free assessment of the tissue's morphochemical composition and allows early-stage and automatic detection of disease. For clinical intraoperative application, compact devices are required.

Identifying the Role of Individual Seal IAPP Amino Acids in Inhibiting the Aggregation of Human IAPP.

Introduction: The progression of type 2 diabetes in humans appears to be linked to the loss of insulin-producing β-cells. One of the major contributors to β-cell loss is the formation of toxic human IAPP amyloid (hIAPP, Islet Amyloid Polypeptide, amylin) in the pancreas. Inhibiting the formation of toxic hIAPP amyloid could slow, if not prevent altogether, the progression of type 2 diabetes.