Publications by authors named "J A Cricco"
Article Synopsis
- Trypanosoma cruzi, the parasite causing Chagas disease, relies on copper (Cu) for growth and development, but its levels must be carefully controlled due to potential toxicity.
- The study found that Cu is crucial for the proliferation of the epimastigote stage and the transition to the metacyclic form, but the intracellular amastigote stage experiences copper stress during infection.
- Researchers identified key gene products related to copper metabolism, such as TcCuATPase for copper export and suggested TcIT as a possible copper importer, highlighting a unique model of copper transport and distribution in T. cruzi.
Article Synopsis
- Trypanosoma cruzi, a parasite reliant on heme, regulates its heme levels by adjusting the expression of a specific protein called TcHRG when exposed to free heme in culture.
- The study found that TcHRG responds similarly to both bound (hemoglobin) and free heme, located near the flagellar pocket and mitochondria.
- Interestingly, despite the absence of endocytosis, parasites can still acquire heme from hemoglobin, suggesting that TcHRG plays a key role in breaking down hemoglobin to extract heme from outside the cell through the flagellar pocket.
, a heme auxotrophic parasite, can control intracellular heme content by modulating HRG expression when a free heme source is added to axenic culture. Herein, we explore the role of HRG protein in regulating the uptake of heme derived from hemoglobin in epimastigotes. It was found that the parasités endogenous HRG (protein and mRNA) responds similarly to bound (hemoglobin) and free (hemin) heme.
View Article and Find Full Text PDFWe have previously shown that prenyl and aliphatic triazoles are interesting motifs to prepare new chemical entities for antiparasitic and antituberculosis drug development. In this opportunity a new series of prenyl-1,2,3-triazoles were prepared from isoprenyl azides and different alkynes looking for new antimalarial drug candidates. The compounds were prepared by copper(i) catalyzed dipolar cycloaddition of the isoprenyl azide equilibrium mixture providing exclusively 1,4-disubstituted 1,2,3-triazoles in a regiospecific fashion.
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