Publications by authors named "J A Crabtree"
Article Synopsis
- Intense wildfires are increasingly impacting air quality, raising concerns about potential negative effects on cardiopulmonary health for people exposed to smoke, particularly in the Eastern US.
- A study aimed to examine the relationship between smoke from wildfires in Western Canada and respiratory diseases in various demographic groups in Eastern US populations, using data from the University of Maryland Medical System.
- Findings showed significantly higher rates of cardiopulmonary clinical encounters during "hotspot days" with elevated PM2.5 levels, indicating a correlation between increased pollution and health issues, especially during notable air quality deteriorations in June 2023.
Article Synopsis
- * It achieves a high level of completeness, closing 92% of previous assembly gaps and fully assembling complex regions, including 1,852 complex structural variants and 1,246 human centromeres.
- * The findings lead to significant improvements in genotyping accuracy and enable the detection of over 26,000 structural variants per sample, enhancing the potential for future disease association research.
Through their eyes: Navigating life with limited eyelid closure in patients with Moebius syndrome.
J Plast Reconstr Aesthet Surg
November 2024
Article Synopsis
- Moebius syndrome (MoS) is a rare condition that affects facial movement and causes problems with closing the eyelids, making it hard for people to fully blink.
- A study was done with 15 people at a conference to learn about their experiences living with this condition, and they discussed how it affects their daily lives and how society sees them.
- The researchers noted that many participants felt a mix of challenges, like social stigma, and had different opinions on surgery, but many also showed a strong sense of self-acceptance about their situation.
Loss of glucose-stimulated β-cell Nr4a1 expression impairs insulin secretion and glucose homeostasis.
Am J Physiol Cell Physiol
October 2024
A central aspect of type 2 diabetes is decreased functional β-cell mass. The orphan nuclear receptor Nr4a1 is critical for fuel utilization, but little is known regarding its regulation and function in the β-cell. Nr4a1 expression is decreased in type 2 diabetes rodent β-cells and type 2 diabetes patient islets.
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