Dementia Care Research and Psychosocial Factors.

Background: Although cognitive decline is a trait related to aging, some individuals are resilient to the aging process, defined as SuperAgers. Studying the neural underpinnings of SuperAgers may improve the understanding of AD pathology. In this study, our aim was to analyze amyloid and neurodegeneration imaging biomarkers in SuperAgers.

The Role of ctDNA in the Management of Non-Small-Cell Lung Cancer in the AI and NGS Era.

Liquid biopsy (LB) involves the analysis of circulating tumour-derived DNA (ctDNA), providing a minimally invasive method for gathering both quantitative and qualitative information. Genomic analysis of ctDNA through next-generation sequencing (NGS) enables comprehensive genetic profiling of tumours, including non-driver alterations that offer prognostic insights. LB can be applied in both early-stage disease settings, for the diagnosis and monitoring of minimal residual disease (MRD), and advanced disease settings, for monitoring treatment response and understanding the mechanisms behind disease progression and tumour heterogeneity.

Comparing Different Data Partitioning Strategies for Segmenting Areas Affected by COVID-19 in CT Scans.

Background/objectives: According to the World Health Organization, the gold standard for diagnosing COVID-19 is the Reverse Transcription Polymerase Chain Reaction (RT-PCR) test. However, to confirm the diagnosis in patients who have negative results but still show symptoms, imaging tests, especially computed tomography (CT), are used. In this study, using convolutional neural networks, we compared the following topics using manual and automatic lung segmentation methods: (1) the performance of an automatic segmentation of COVID-19 areas using two strategies for data partitioning, CT scans, and slice strategies; (2) the performance of an automatic segmentation method of COVID-19 when there was interobserver agreement between two groups of radiologists; and (3) the performance of the area affected by COVID-19.

Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation.

Background And Aim: Pregnancy after the age of 35 is correlated with an increased risk of impaired placentation and the development of pregnancy-associated complications. Changes in uterine redox balance seem to play a role in these settings. In this work, we hypothesized that local redox dysregulation impacts the placenta metabolic profile.

How well is the female population represented in clinical trials with infusion therapies for Parkinson's disease? A systematic review and metanalysis.

Background: Parkinson's disease (PD) is a neurodegenerative disorder affecting both sexes, but differences exist between male and female in clinical manifestations, functional impact of symptoms and hormonal influences. Therefore, representativeness of females in PD trials indirectly determines the external validity of the clinical research in this field.

Objective: To estimate the representativeness of female in infusion therapy trials for advanced PD.