Publications by authors named "J A Coppinger"
Objective: The objective of this study was to examine clinicians' patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and ApoE blood biomarkers combined with patient age (PrecivityAD® blood test) in symptomatic patients evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.
Methods: The Quality Improvement and Clinical Utility PrecivityAD Clinician Survey (QUIP I, ClinicalTrials.gov Identifier: NCT05477056) was a prospective, single-arm cohort study among 366 patients evaluated by neurologists and other cognitive specialists.
Article Synopsis
- Extracellular vesicles (EVs) from blood show promise as diagnostic biomarkers for cystic fibrosis (CF), especially as traditional sputum tests become less viable due to effective therapies.
- *Using size exclusion chromatography, researchers isolated more EVs from serum than via ultracentrifugation and analyzed their quantities and protein expressions in different age groups of CF patients.
- *The study found significant protein expression differences between children and adults with CF, suggesting serum EVs could be valuable for monitoring disease progression and treatment responses.*
Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a misfolded rhodopsin protein that photoreceptors quickly target for degradation by mechanisms that are incompletely understood. To gain insight into how P23H rhodopsin is removed from rods, we used mass spectrometry to identify protein interaction partners of P23H rhodopsin immunopurified from Rho mice and compared them with protein interaction partners of wild-type rhodopsin from Rho mice.
View Article and Find Full Text PDFSARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction of neuronal axon degeneration in response to a variety of injuries. We recently demonstrated that SARM1 is pro-degenerative in a genetic model of inherited retinopathy.
View Article and Find Full Text PDFTo explore the role of extracellular vesicles (EVs) in chronic lung diseases.EVs are emerging as mediators of intercellular communication and possible diagnostic markers of disease. EVs harbour cargo molecules including RNA, lipids and proteins that they transfer to recipient cells.
View Article and Find Full Text PDF