Publications by authors named "J A Clements"
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.
View Article and Find Full Text PDFBackground: Prostate cancer (PCa) is a commonly diagnosed cancer. Genome-wide association studies have implicated Iroquois homeobox 4 (IRX4) in PCa susceptibility, yet its functional roles remain unclear. We discovered a 78-amino acid micropeptide (miPEP, IRX4_PEP1), encoded from the alternative start site within the IRX4 gene.
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- Viral encephalitis poses a significant public health concern, especially with limited diagnostic and treatment methods available.
- SIV-infected macaques serve as a model for studying HIV, with about 60% of untreated pigtail macaques rapidly developing SIV encephalitis (SIVE).
- Research shows that immune responses in SIVE macaques lead to specific brain lesions and inflammatory markers, and the presence of SIV-specific IgG antibodies can predict SIVE development as early as 21 days post-infection.
Background: Monocytes are susceptible to HIV infection, form HIV reservoirs, and contribute to central nervous system complications (e.g., cognitive impairment) in virally suppressed women with HIV(vsWWH).
View Article and Find Full Text PDFCancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as the Warburg effect. This metabolic reprogramming is a crucial adaptation that enables cancer cells to meet their elevated energy and biosynthetic demands. Importantly, the tumor microenvironment plays a pivotal role in shaping and sustaining this metabolic shift in cancer cells.
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