Tailoring membrane technology with galactomannan for enhanced biocompatibility and antibacterial action.

In this study, we elaborated advanced asymmetric membranes using polyvinyl alcohol (PVA) and a galactomannan (GA) derived from Delonix regia seeds, a blend known for its biocompatibility properties. These membranes, crosslinked with sulfosuccinic acid (SSA), exhibited remarkable enhancements in various crucial aspects for biomedical applications, in particular provides antibacterial properties. The incorporation of GA leads to the formation of globular regions, enhancing crosslinking and swelling properties.

The biological applications of IPN hydrogels.

Background And Purpose: Interpenetrating polymer network (IPN) hydrogels are an adaptable category of materials, exhibiting remarkable promise for various biological applications due to their distinctive structural and functional attributes. This review delves into the synthesis of IPN hydrogels through both physical and chemical methodologies, elucidating how these techniques allow for precise tailoring of mechanical properties, swelling behaviour, and biocompatibility.

Experimental Approach: We conducted an extensive literature review by searching well-established online research databases for articles published since 2009 to gather comprehensive data on IPN hydrogels.

Collagen-β-cyclodextrin hydrogels for advanced wound dressings: super-swelling, antibacterial action, inflammation modulation, and controlled drug release.

A key strategy in enhancing the efficacy of collagen-based hydrogels involves incorporating polysaccharides, which have shown great promise for wound healing. In this study, semi-interpenetrating polymeric network (semi-IPN) hydrogels comprised of collagen (Col) with the macrocyclic oligosaccharide β-cyclodextrin (β-CD) (20-80 wt.%) were synthesised.

Modulation of the biocompatibility of collagen/polyelectrolyte semi-IPN hydrogels with Zn-bioMOFs.

Background And Purpose: In this study, we examined the impact of Zn-bioMOF structures on the physical and chemical characteristics as well as the biocompatibility of a matrix composed of semi-interpenetrating polymeric networks (semi-IPN) made from collagen and L-tyrosine-based polyelectrolytes.

Experimental Approach: We hydrothermally synthesized L-1, ZIF-8H Zn-bioMOFs, and the Zn-(L-His) complex, utilizing L-histidine, a bioactive amino acid, as a ligand. These metal-organic compounds primarily enhance the mechanical properties of the novel composite hydrogels through physical interactions such as hydrogen bonds and dipolar interactions.

Collagen-polyurethane-dextran hydrogels enhance wound healing by inhibiting inflammation and promoting collagen fibrillogenesis.

Diabetic foot ulcers are a serious complication of uncontrolled diabetes, emphasizing the need to develop wound healing strategies that are not only effective but also biocompatible, biodegradable, and safe. We aimed to create biomatrices composed of semi-interpenetrated polymer networks of collagen, polyurethane, and dextran, to enhance the wound healing process. The hydrogels were extensively characterized by various analytical techniques, including analysis of their structure, crystallinity, thermal properties, gelation process, reticulation, degradation, cell proliferation, and healing properties, among others.