Publications by authors named "J A Cienfuegos"
Background: PIEZO1 has emerged as a mechanoreceptor linked with adipogenesis, adipose tissue (AT) inflammation and insulin resistance. We aimed to determine the impact of obesity and obesity-associated type 2 diabetes (T2D) as well as mechanical compression forces on the expression of PIEZO1 in visceral AT (VAT) and its relation with inflammation.
Methods: Blood and VAT samples were obtained from 100 volunteers.
Article Synopsis
- - Excess body fat contributes to the development of colon cancer (CC) by increasing the expression of the pro-inflammatory cytokine IL-1β, which is linked to obesity-related inflammation and tumor growth.
- - A study involving human samples and a rat model showed that obesity and CC both significantly elevate IL-1β levels in adipose tissue and colon, with weight loss leading to a decrease in IL-1β expression.
- - Treating colon cancer cells (HT-29) with IL-1β and substances from obese patients' fat cells promoted inflammatory markers and reduced anti-inflammatory gene expression, highlighting IL-1β's role in driving inflammation linked to obesity and CC.
Article Synopsis
- * In a study involving 120 rats with diet-induced obesity, SADI-S led to significantly lower body weight, decreased fat mass, and improved insulin sensitivity compared to SG and caloric restriction.
- * The results indicate that SADI-S is more effective than SG or caloric restriction for enhancing glycemic control and overall metabolic health, yielding better long-term outcomes for weight loss and insulin resistance.
Liver transplantation in colorectal metastases. Is there an indication for this procedure?
Rev Esp Enferm Dig
February 2024
Almost 25 % of patients with colorectal cancer present metastases at the time of diagnosis and 50 % go on to develop metastases in the course of the disease. Surgical resection is the only curative treatment although only between 20 % and 30 % of patients present resectable lesions. Although liver transplantation is contraindicated in unresectable metastases of colorectal cancer, ever since the publication of the results of a pilot study there has been renewed interest in transplantation in these patients.
View Article and Find Full Text PDFIntroduction: Obesity contributes to ectopic fat deposition in non-adipose organs, including the pancreas. Pancreas steatosis associates with inflammation and β-cell dysfunction, contributing to the onset of insulin resistance and type 2 diabetes. An improvement of pancreatic steatosis and indices of insulin resistance is observed following bariatric surgery, but the underlying mechanisms remain unknown.
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