Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin.

Channelrhodopsins, light-gated cation channels, enable precise control of neural cell depolarization or hyperpolarization with light in the field of optogenetics. This study integrates time-resolved serial crystallography and atomistic molecular dynamics (MD) simulations to resolve the structural changes during C1C2 channelrhodopsin activation. Our observations reveal that within the crystal environment, C1C2 predominantly remains in a light-activated state with characteristics of the M intermediate.

Preferences for the delivery of early abortion services in Australia: a discrete choice experiment.

Background Abortion is a common procedure in Australia; it is estimated that the rate is between 15 and 17 per 1000 women. Surgical and medical abortion options are available; however, the use of medical abortion is not as common as in other similar countries. The aim of this study is to understand preferences for the provision of early abortion services in Australia.

A generative AI-driven interactive listening assessment task.

Introduction: Assessments of interactional competence have traditionally been limited in large-scale language assessments. The listening portion suffers from construct underrepresentation, whereas the speaking portion suffers from limited task formats such as in-person interviews or role plays. Human-delivered tasks are challenging to administer at large scales, while automated assessments are typically very narrow in their assessment of the construct because they have carried over the limitations of traditional paper-based tasks to digital formats.

Sugar-sweetened beverage consumption in Thailand: Determinants and variation across socioeconomic status.

Objectives: Reducing consumption of sugar-sweetened beverages (SSBs) is a primary public health goal in Thailand, but information on the characteristics of SSB consumers remains limited. This study aims to gain knowledge about the characteristics of SSB consumers in Thailand.

Study Design: Secondary analysis of survey data.