Publications by authors named "J A Charlton"
Introduction: The physiologic derangements imposed by cardiopulmonary bypass (CPB) can result in complications such as postoperative delirium. We aim to validate a rodent survival model of CPB demonstrating a systemic inflammatory response and hypothesize that this contributes to post-CPB delirium.
Methods: Adult Sprague-Dawley rats were randomized to three groups: 1) Sham peripheral surgical cannulation, 2) CPB followed by acute phase harvest, or 3) CPB followed by 24-h survival.
Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).
J Perinatol
October 2024
Article Synopsis
- Delayed cord clamping (DCC) is a common practice during preterm births, but its effects on kidney health are uncertain.
- A study evaluated DCC against early cord clamping (ECC) in preterm infants, focusing on acute kidney injury (AKI) and kidney function at two years.
- Findings indicated that DCC did not reduce the risk of AKI but was linked to a significantly higher chance of reduced kidney function (eGFR <90 mL/min/1.73m) after two years.
Perceptual judgements of the environment emerge from the concerted activity of neural populations in decision-making areas downstream of sensory cortex [1, 2, 3]. When the sensory input is ambiguous, perceptual judgements can be biased by prior expectations shaped by environmental regularities [4, 5, 6, 7, 8, 9,10,11]. These effects are examples of Bayesian inference, a reasoning method in which prior knowledge is leveraged to optimize uncertain decisions [12, 13].
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