Publications by authors named "J A C Zijl"
Article Synopsis
- Clinical rating scales often miss the full range of dystonic symptoms, prompting the need for a reliable biomarker to assess the effectiveness of deep brain stimulation (GPi-DBS) for treating dystonia.
- In a study of 12 patients undergoing GPi-DBS, researchers found that those with arm dystonia had higher intermuscular coherence in the 4-12 Hz range before surgery, which significantly decreased after the procedure.
- Despite the observed changes in coherence, the study found no strong links between coherence levels and clinical rating scale scores, suggesting that more research is needed to determine the biomarker's clinical utility.
A challenge of any biosensing technology is the detection of very low concentrations of analytes. The fluorescence interference contrast (FLIC) technique improves the fluorescence-based sensitivity by selectively amplifying, or suppressing, the emission of a fluorophore-labeled biomolecule immobilized on a transparent layer placed on top of a mirror basal surface. The standing wave of the reflected emission light means that the height of the transparent layer operates as a surface-embedded optical filter for the fluorescence signal.
View Article and Find Full Text PDFBackground: Magnetic resonance imaging (MRI) has shown limited diagnostic accuracy for multiple ligament knee injuries (MLKIs), especially posterolateral corner (PLC) injuries.
Hypothesis: The diagnostic accuracy of MRI for MLKIs will only be moderate for some knee structures. Patient-related factors and injury patterns could modify the diagnostic accuracy of MRI.
Objective: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment in advanced Parkinson's disease (PD). However, the clinical outcome after STN-DBS is variable. The aim of this study was to explore the coherence of antagonistic muscles measured with electromyography (EMG) as novel biomarker of STN-DBS efficacy in PD.
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