Publications by authors named "J A Butera"
Article Synopsis
- Malaria is a significant health issue in sub-Saharan Africa, with asymptomatic infections contributing to ongoing transmission challenges, especially as non-falciparum malaria becomes more prevalent.
- A study in Rwanda analyzed 4,596 individuals using quantitative PCR and found a 23.6% overall malaria infection rate, with asymptomatic falciparum malaria being widespread and low mixed-species infections common.
- The findings highlight the need for ongoing monitoring of malaria species, emphasizing the connection between falciparum infections and factors like socio-economic status and location.
Article Synopsis
- - The study investigates the early distribution of artemisinin resistance mutations, specifically R561H, in Rwanda, which was first identified in 2014 but had unclear geographic spread.
- - Researchers analyzed dried blood spot samples from a national HIV study conducted between 2014-2015, identifying multiple malaria infections and sequencing a significant number of samples to track mutations.
- - Findings reveal that R561H was not only present in the previously reported area of Masaka but also in higher-transmission regions in southeastern Rwanda, highlighting a broader spread of this mutation than previously understood.
While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML-specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid-phase BM stroma. We assessed the effect of anthracycline- and cytarabine-based induction chemotherapy on both haematopoietic and non-haematopoietic cells directly in core BM biopsies using RNA-seq and histological analysis. We compared matched human core BM biopsies at diagnosis and 2 weeks after cytarabine- and anthracycline-based induction therapy in responders (<5% blasts present after treatment) and non-responders (≥5% blasts present after treatment).
View Article and Find Full Text PDFGood physician-patient communication is key for effective hospital care. We describe a patient diagnosed with an acute pulmonary embolism and bacteremia who was treated in a virtual hybrid hospital-at-home program. Constant communication with the virtual and in-home healthcare teams enabled a unified knowledge of the patient's wishes.
View Article and Find Full Text PDFBackground: We conducted an investigator-initiated, phase I trial of vincristine sulfate liposomal injection (VSLI) in combination with bendamustine and rituximab (BR) for indolent B-cell (BCL) or mantle cell lymphoma.
Methods: Participants received 6 cycles of standard BR with VSLI at patient-specific dose determined by the Escalation with Overdose Control (EWOC) model targeting 33% probability of dose-limiting toxicity (DLT). Maximum tolerated dose (MTD) was the primary endpoint; secondary endpoints included rates of adverse events (AEs), overall response rate (ORR), and complete response (CR).