TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast.

The target of rapamycin (TOR) signalling pathway plays a key role in the coordination between cellular growth and the cell cycle machinery in eukaryotes. The underlying molecular mechanisms by which TOR might regulate events after anaphase remain unknown. We show for the first time that one of the 2 TOR complexes in budding yeast, TORC1, blocks the separation of cells following cytokinesis by phosphorylation of a member of the NDR (nuclear Dbf2-related) protein-kinase family, the protein Cbk1.

We need to change how we compute RMSEA for nested model comparisons in structural equation modeling.

Comparison of nested models is common in applications of structural equation modeling (SEM). When two models are nested, model comparison can be done via a chi-square difference test or by comparing indices of approximate fit. The advantage of fit indices is that they permit some amount of misspecification in the additional constraints imposed on the model, which is a more realistic scenario.

Polyethylene Terephthalate (PET) Bottle-to-Bottle Recycling for the Beverage Industry: A Review.

Disposal of plastic waste has become a widely discussed issue, due to the potential environmental impact of improper waste disposal. Polyethylene terephthalate (PET) packaging accounted for 44.7% of single-serve beverage packaging in the US in 2021, and 12% of global solid waste.

A multipurpose dressing: role of a Hydrofiber foam dressing in managing wound exudate.

Chronic wound exudate is associated with stalled or delayed healing. Excess amounts will break down healthy tissue, increasing the production of slough and necrotic tissue. This will also create an ideal environment for microbial proliferation and place the surrounding skin at risk of maceration.

Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809.

The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogues derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), were synthesized and evaluated for CFTR modulation. Triazole 11, derived from VX-809, displayed markedly reduced efficacy in F508del-CFTR correction in cellular TECC assays in comparison to VX-809.