Publications by authors named "J A Bogan"
Article Synopsis
- The eastern indigo snake, once widespread in the southeastern US, is now primarily found in southeastern Georgia and Florida and is considered federally threatened.
- Concerns exist about how diet and nutrition affect the reproductive health of these snakes, particularly regarding issues like dystocia in females that have never bred.
- A year-long study compared the health and nutrient levels of snakes on different diets, finding that while some nutrients were adequate, others—particularly vitamin D—were lower than those found in wild counterparts, suggesting further research on juvenile diets is needed to better understand nutrition's impact on reproduction.
Article Synopsis
- RIG-I-like receptors (RLRs) in the cytoplasm detect viral RNA and kickstart the body's initial antiviral defenses, but their interaction with glucose transporters (GLUTs) in immunity has been unclear.
- The study reveals that GLUT4, which responds to insulin, can inhibit RLR signaling without needing to uptake glucose, particularly when it is trapped in the Golgi until a viral infection occurs.
- The findings suggest that GLUT4's relocation affects the immune response to viruses, with implications for conditions like inflammatory myopathies where GLUT4 expression is lower, leading to increased interferon activity.
Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.
Obesity (Silver Spring)
December 2024
Objective: Caloric restriction (CR) is known to enhance insulin sensitivity and reduce the risk of metabolic disorders; however, its molecular mechanisms are not fully understood. This study aims to elucidate specific proteins and pathways responsible for these benefits.
Methods: We examined adipose tissue from participants in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE 2) study, comparing proteomic profiles from individuals after 12 and 24 months of CR with baseline and an ad libitum group.
Article Synopsis
- * Viral infections, such as adenoviruses and reoviruses, could potentially weaken the snakes' immune systems and worsen the disease, but this study focused on screening for these viruses in EISs.
- * The results showed that while adenoviruses were found in some snakes, their presence did not significantly influence the health or survival of EISs or contribute to the progression of gastric cryptosporidiosis.
Background: Deep brain stimulation (DBS), the direct electrical stimulation of neuronal tissue in the basal forebrain to enhance release of the neurotransmitter acetylcholine, is under consideration as a method to improve executive function in patients with dementia. While some small studies indicate a positive response in the clinical setting, the relationship between DBS and acetylcholine pharmacokinetics is incompletely understood.
Objective: We examined the cortical acetylcholine response to different stimulation parameters of the basal forebrain.