Dietary regulation of silent synapses in the dorsolateral striatum.

Obesity and drugs of abuse share overlapping neural circuits and behaviors. Silent synapses are transient synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood.

The Electrochemical Peroxydisulfate-Oxalate Autocatalytic Reaction.

Aqueous solutions containing both the strong oxidant, peroxydisulfate (SO), and the strong reductant, oxalate (CO), are thermodynamically unstable due to the highly exothermic homogeneous redox reaction: SO + CO → 2 SO + 2 CO (Δ = -490 kJ/mol). However, at room temperature, this reaction does not occur to a significant extent over the time scale of a day due to its inherently slow kinetics. We demonstrate that the SO/CO redox reaction occurs rapidly, once initiated by the Ru(NH)-mediated 1e reduction of SO to form SO, which rapidly undergoes bond cleavage to form SO and the highly oxidizing radical SO.

DIETARY REGULATION OF SILENT SYNAPSES IN THE DORSOLATERAL STRIATUM.

Obesity and drugs of abuse share overlapping neural circuits and behaviors. Silent synapses are transient synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood.

ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation.

Motivation: The acquisition of somatic mutations in hematopoietic stem and progenitor stem cells with resultant clonal expansion, termed clonal hematopoiesis (CH), is associated with increased risk of hematologic malignancies and other adverse outcomes. CH is generally present at low allelic fractions, but clonal expansion and acquisition of additional mutations leads to hematologic cancers in a small proportion of individuals. With high depth and high sensitivity sequencing, CH can be detected in most adults and its clonal trajectory mapped over time.