Routine use of jejunostomy tubes after esophagectomy: The good, the bad, and the ugly!

Objective: The study objective was to assess adverse events, readmissions, and resource use associated with routine jejunostomy tube placement after esophagectomy.

Methods: From September 2018 to October 2021, 215 patients, with a median age of 65 years and a median body mass index of 27 kg/m, underwent routine jejunostomy tube placement during esophagectomy. J-tube-related adverse events were collected from date of surgery to date of removal and categorized as (1) nonserious, resource-nonintensive (eg, skin irritations, discomfort); (2) nonserious, resource-intensive (eg, infection, clogged, and dislodged tubes); and (3) serious, resource-intensive (eg, bowel obstruction, volvulus, tube feed intolerance).

Spontaneous subaponeurotic fluid collection in an infant: illustrative case.

Background: Spontaneous subaponeurotic fluid collections (SSFCs) are benign, typically self-limiting fluid collections beneath the scalp's aponeurosis. Their abrupt onset and unusual appearance can cause significant alarm and suspicion of considerable pathology or child abuse. With an unclear etiology and concerning clinical presentation, it is important to recognize SSFCs as a unique condition, distinct from those that require immediate neurosurgical intervention.

The Healthcare Integrated Research Database (HIRD) as a Real-World Data Source for Pharmacoepidemiologic Research.

Background And Methods: The Healthcare Integrated Research Database (HIRD) is a large, comprehensive real-world data (RWD) source for health-related research. Demographic and healthcare-related characteristics of individuals are sourced from routinely updated RWD. The HIRD includes health insurance claims and other health-related information for individuals enrolled in health insurance plans offered or managed by Elevance Health and has been utilized for research for almost two decades.

Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use.

Psychedelic drugs are currently being explored for their therapeutic potential for a variety of health conditions. The recent increased public interest in psychedelics necessitates empirical investigation into motivations for use among users as well as how motivations may change over time. We asked a large sample of participants reporting naturalistic psychedelic use ( = 1221) about their motivations for using psychedelics initially (i.

Huntingtin plays an essential role in the adult hippocampus.

The consequences of non-pathogenic huntingtin (HTT) reduction in the mature brain are of substantial importance as clinical trials for numerous HTT-lowering therapies are underway; many of which are non-selective in that they reduce both mutant and wild type protein variants. In this study, we injected CaMKII-promoted AAV-Cre directly into the hippocampus of adult HTT floxed mice to explore the role of wild-type huntingtin (wtHTT) in adult hippocampal pyramidal neurons and the broader implications of its loss. Our findings reveal that wtHTT depletion results in profound macroscopic morphological abnormalities in hippocampal structure, accompanied by significant reactive gliosis.