Publications by authors named "J A Barcia"
This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy.
View Article and Find Full Text PDFExosomes or small extracellular vesicles (sEVs) represent a pivotal component in intercellular communication, carrying a diverse array of biomolecules. Several factors can affect sEVs release dynamics, as occurs in hyperglycemia or inflammation. In fact, sEVs release has been associated with the promotion of physio-pathological processes.
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- Deep brain stimulation (DBS) is being explored as an effective treatment for severe obsessive-compulsive disorder (OCD), with various potential targets in the brain, especially around the anterior limb of the internal capsule and ventral striatum.
- A study involving 82 OCD patients identified two key stimulation sites linked to significant symptom improvements: one near the anterior limb of the internal capsule and another near the inferior thalamic peduncle, while also showing that stimulation at certain locations can lead to better outcomes for depression and anxiety.
- The findings suggest that refining the targeting of DBS could enhance treatment effectiveness and help optimize DBS programming for patients already receiving therapy.
Deep-brain stimulation (DBS) is a potential novel treatment for memory dysfunction. Current attempts to enhance memory focus on stimulating human hippocampus or entorhinal cortex. However, an alternative strategy is to stimulate brain areas providing modulatory inputs to medial temporal memory-related structures, such as the nucleus accumbens (NAc), which is implicated in enhancing episodic memory encoding.
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