Publications by authors named "J A B Patricio"

Article Synopsis
  • Mitochondria play a key role in metabolic processes necessary for cell health and growth.
  • Researchers studied how human cells react to mitochondrial dysfunction by examining metabolomics in fibroblasts from patients with mitochondrial disorders and cancer cells with disrupted electron transport chains (ETC).
  • The findings showed that ETC defects lower de novo purine synthesis while increasing purine salvage, highlighting a shift in metabolism, particularly in lung cancer cells expressing high levels of the enzyme HPRT1, which is crucial for purine salvage.
  • Targeting HPRT1 makes cancer cells more sensitive to ETC inhibition, revealing a new potential weakness in tumors with low oxidative metabolism.
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Introduction Ventilator-associated pneumonia (VAP) is the most common infectious complication related to admission to an Intensive Treatment Unit (ITU). Ventilator-associated lower respiratory tract infection (VA-LRTI) is a broader diagnosis than VAP. By disregarding radiological criteria, it will include both VAP and ventilator-associated tracheobronchitis.

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Coronary vasospasm is a well-recognized cause of angina (also known as Prinzmetal angina) and a common cause of admissions to the emergency department and coronary intensive care units. It is however an uncommon cause of cardiac arrest. We describe a patient with multiple episodes of chest pain followed by cardiac arrest in pulseless electrical activity (PEA) due to coronary vasospasm.

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Individuals' perceptions of their social images [i.e., meta-representations (MR)] and perceived stereotyping threat create involuntary stress responses that may affect important outcomes, such as self-esteem, academic achievement, and mental health.

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Purpose: De novo lipogenesis (DNL) is critical for cell growth and maintenance, and acetyl-CoA precursors can be derived from different substrates. We developed a C NMR analysis of lipid extracts from cultured microglia cells administered with [U- C]glucose that informs overall lipogenic activity as well as the contribution of glucose to lipogenic acetyl-CoA.

Methods: BV-2 microglial cell line cultured with glucose and glutamine was provided with [U- C]glucose and unlabeled glutamine for 24 h and studied in either the presence or absence of lipopolysaccharide (LPS).

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