Publications by authors named "J A Avila-Funes"
Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer's disease and frontotemporal lobe degeneration from Latin America and the United States.
View Article and Find Full Text PDFThe growing incidence of cognitive impairment among older adults has a significant impact on individuals, family members, caregivers, and society. Current conventional cognitive assessment tools are faced with some limitations. Recent evidence suggests that automating cognitive assessment holds promise, potentially resulting in earlier diagnosis, timely intervention, improved patient outcomes, and higher chances of response to treatment.
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- - The study investigated the cognitive profiles of older people with HIV (OPWH) undergoing combined antiretroviral therapy, focusing on how age interacts with HIV-related cognitive disorders.
- - Researchers conducted a cross-sectional analysis of 330 OPWH aged 50 and older, using neuropsychological tests to evaluate cognitive functions and identify clusters of cognitive impairment.
- - Results showed three distinct cognitive clusters: one with significant memory impairments, another with language and abstraction issues, and a third with no specific domain impairments, suggesting variations based on both HIV-related and other individual factors.
Article Synopsis
- Latin America's genetic diversity offers a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD), with a focus on identifying related genetic variations.
- The study involved 2,162 participants from six countries who underwent extensive genomic sequencing and analysis to detect genetic factors linked to these dementias.
- Results highlighted a mix of American, African, and European ancestries, discovered 17 pathogenic variants, and revealed specific genetic variations tied to AD and FTD inheritance patterns in affected families.
Purpose: To ascertain the association between the LT-CD4 + /CD8 + ratio and cognitive impairment in older people living with HIV.
Methods: A cross-sectional study was conducted, including 207 adults aged > 50 years with HIV, receiving care at a tertiary-care hospital in Mexico City. Participants underwent a standardized geriatric and neuropsychological assessment to establish the presence of HIV-associated neurocognitive disorder according to the validated Antinori criteria.