Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.

Acute brain injury (ABI) is a complex disease process that begins with an initial insult followed by secondary injury resulting from disturbances in cerebral physiology. In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insight to adjust therapeutic interventions and reduce risk of ischemia and permanent injury. Current established approaches for monitoring cerebral physiology include the neurologic physical examination, traditional brain imaging such as computed tomography (CT) and magnetic resonance imaging (MRI), electroencephalography (EEG), and bedside modalities such as invasive parenchymal probes and transcranial doppler ultrasound.

A paradoxical misperception of relative motion.

Detecting the motion of an object relative to a world-fixed frame of reference is an exquisite human capability [G. E. Legge, F.

Faculty Reflections on What Makes a Good Surgeon: "The operating Room is Often the Smallest Part of the Puzzle".

Objective: Little research has inductively investigated the unique nontechnical qualities required of a surgeon holistic to their practice. This is problematic because there may be additional nuances, or entirely new attributes, that can only be identified in the authentic context of surgical practice. The aim of this study was to investigate the unique nontechnical qualities required of surgeons holistic to their practice.

Modeling and techno-economic analysis of downstream manufacturing process intensification strategies for existing biopharmaceutical facilities.

Downstream process (DSP) intensification technologies have the potential to provide faster, more sustainable, and more profitable processes. Nevertheless, the calculation of the possible benefits obtained from the implementation of these technologies is not always evident and usually depends on a particular production scenario. In the present work, we developed a framework for techno-economic feasibility analysis to assess the impact of changes in protein A capture, polishing, and viral filtration on process performance.

Transcatheter Pulmonary Valve Replacement in Middle and Late Adulthood.

Transcatheter pulmonary valve replacement (TPVR) is now frequently performed in patients with adult congenital heart disease. As the life expectancy of the population with adult congenital heart disease continues to improve, more patients will require pulmonary valve intervention. This study details the short-term and midterm clinical outcomes of patients aged ≥40 years who underwent TPVR.