Publications by authors named "J A Ajiboye"
Article Synopsis
- Cryptosporidium parvum and C. hominis are dangerous parasites causing severe diarrhea, particularly in children and people with weakened immune systems, with limited treatment options available.
- Researchers screened 278 compounds and discovered that certain pyrazolopyrimidine human phosphodiesterase (PDE)-V inhibitors showed strong effectiveness against these parasites in infected mice, targeting their ability to exit host cells and demonstrating minimal side effects.
- The study identified CpPDE1 as a crucial target for these inhibitors, as mutations in this enzyme affect the efficiency of treatment, opening new avenues for developing more effective therapies against Cryptosporidium infections.
Article Synopsis
- The text discusses an apicomplexan parasite that causes persistent diarrhea, focusing on developing calcium-dependent protein kinase 1 inhibitors, known as bumped kinase inhibitors (BKIs), which show promise in combating this parasite.
- BKI-1748, a specific inhibitor, shares similarities with quinine but has better efficacy against the parasite without the severe side effects associated with quinine, and it significantly affects the structure of the parasite.
- Research using mass spectrometry identified several proteins that BKI-1748 binds to, particularly those involved in RNA binding and modification, suggesting it interacts with crucial cellular processes like translation and RNA processing.
Background: Many sub-Saharan African patients receive clinical care from extramurally-supported research and surveillance. Dur- ing the COVID-19 pandemic, pausing these activities reduces pa- tient care, surveillance, and research staff employment, increasing pandemic losses. In Oyo State, Nigeria, we paused a multi-country invasive salmonellosis surveillance initiative and a rural clinical bac- teriology project.
View Article and Find Full Text PDFThe administration and governance of grant funding across global health organizations presents enormous challenges. Meeting these challenges is crucial to ensuring that funds are used in the most effective way to improve health outcomes, in line with the United Nations' Sustainable Development Goal 3, "Ensure healthy lives and promote well-being for all at all ages." The Good Financial Grant Practice (GFGP) Standard (ARS 1651) is the world's first and, currently, only international standard for the financial governance and management of grant funding.
View Article and Find Full Text PDFAim: Fansidar (FAN) is widely used as an antimalarial drug, but it may cause hepatoxicity, nephrotoxicity, and neurotoxicity. Hence, the study examines the cytoprotection of selenium (Se) and zinc (Zn) tablets against FAN induced toxicity.
Method: Group I was given distilled water.