Analytical validation of HER2DX genomic test for early-stage HER2-positive breast cancer.

Background: HER2DX, a multianalyte genomic test, has been clinically validated to predict breast cancer recurrence risk (relapse risk score), the probability of achieving pathological complete response post-neoadjuvant therapy (pCR likelihood score), and individual ERBB2 messenger RNA (mRNA) expression levels in patients with early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This study delves into the comprehensive analysis of HER2DX's analytical performance.

Materials And Methods: Precision and reproducibility of HER2DX risk, pCR, and ERBB2 mRNA scores were assessed within and between laboratories using formalin-fixed paraffin-embedded (FFPE) tumor tissues and purified RNA.

Comparing the MAMS framework with the combination method in multi-arm adaptive trials with binary outcomes.

In multi-arm adaptive trials, several treatments are assessed simultaneously and accumulating data are used to inform decisions about the trial, such as whether treatments are dropped or continued. Different methodological approaches have been developed for such trials and research has compared the performance of different subsets of these. One particular approach, for which we use the acronym MAMS(R), has generally not been included in these comparisons because control of the family-wise error rate (FWER) could not be guaranteed.

The Cherwell splint: an ankle and foot orthosis for rheumatoid arthritis.

Rheumatoid arthritis often gives rise to painful collapse or partial collapse of the foot into valgus under load-bearing conditions, limiting the subject's ability to walk. However, the ankle joint frequently remains unimpaired. Thus, in serious cases a cosmetic splint is required which supports the foot whilst allowing the ankle to plantarflex and dorsiflex.

Influence of the hamstring muscles on lumbar spine curvature in sitting.

The hamstring muscles can restrict hip flexion, especially when the knees are extended. It was hypothesized that individuals with short or tight hamstrings would have abnormal tilting of the pelvis in some seated postures, with greater flattening or reversal of the lumbar lordosis. Healthy adults were studied.