Publications by authors named "J 't Lam-Boer"
Article Synopsis
- The CAIRO4 study aimed to determine if upfront primary tumor resection (PTR) combined with systemic therapy improves overall survival in patients with synchronous unresectable metastatic colorectal cancer (mCRC).
- Conducted in The Netherlands and Denmark, the trial involved 206 patients who were randomly assigned to receive either PTR plus systemic therapy or systemic therapy alone, with the primary endpoint being overall survival.
- Results showed that median overall survival was slightly higher for the upfront PTR group (20.1 months) compared to the no PTR group (18.3 months), but the difference was not statistically significant (P = 0.32), indicating no clear benefit from adding PTR to treatment.
Background: As the outcome of modern colorectal cancer (CRC) surgery has significantly improved over the years, however, renewed and adequate risk stratification for mortality is important to identify high-risk patients. This population-based study was conducted to analyse postoperative outcomes in patients with CRC and to create a risk model for 30-day mortality.
Methods: Data from the Dutch Colorectal Audit were used to assess differences in postoperative outcomes (30-day mortality, hospital stay, blood transfusion, postoperative complications) in patients with CRC treated from 2009 to 2017.
Importance: The role of primary tumor resection (PTR) in synchronous patients with metastatic colorectal cancer (mCRC) who had unresectable metastases and few or absent symptoms of their primary tumor is unclear. Studying subgroups with low postoperative mortality may identify patients who potentially benefit from PTR.
Objective: To determine the difference in 60-day mortality between patients randomized to systemic treatment only vs PTR followed by systemic treatment, and to explore risk factors associated with 60-day mortality.
Introduction: Neoadjuvant chemotherapy (CT) for locally advanced colon cancer (LACC) could potentially lead to tumor shrinkage, eradication of micrometastases, and prevention of tumor cell shedding during surgery. This retrospective study investigates the surgical and oncological outcomes of preoperative CT for LACC.
Methods: Using the Netherlands Cancer Registry, data of patients with stage II or III colon cancer, diagnosed between 2008 and 2016 was collected.