Objective: To determine whether a minimal intervention based on the data envelopment analysis (DEA)-identified efficiency score effectively prevents hypertension.
Design: Randomised controlled trial.
Setting: Takahata town (Yamagata, Japan).
Conditioned flavor preference (CFP) is established by association: where a neutral flavor (conditioned stimulus, CS) is paired with orosensory and post-ingestive components of nutrients, including sugar and fat (unconditioned stimulus, US). A previous study reported that rats can learn to prefer flavors that they consumed earlier and later in a multi-flavored solution paired with an intragastric infusion of glucose, but they expressed only a preference for a late-consumed flavor when they were tested after feeding (Myers and Whitney, 2011). This paradigm can be a suitable rodent model to explain how humans acquire a selective preference for routinely late-served "dessert" foods and why these foods remain attractive even in the absence of hunger.
View Article and Find Full Text PDFIntroduction: Warfarin is characterized by a large inter-individual variability in dosage requirement. This study aimed to analyze the contribution of the CYP4F2 genetic polymorphism and plasma vitamin K concentration on the warfarin pharmacodynamics in patients and to clarify the plasma vitamin K concentration affecting warfarin sensitivity index in rats.
Materials And Methods: Genetic analyses of selected genes were performed and plasma concentrations of warfarin, vitamin K1 (VK1) and menaquinone-4 (MK-4) were measured in 217 Japanese patients.
The aim of this study was to reveal the contribution of CYP4F2, CYP2C9, and VKORC1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of warfarin in Japanese pediatric patients. Genetic analyses of CYP4F2 (rs2108622), CYP2C9 (*2 and *3), and VKORC1 (-1639G>A) were performed, and plasma unbound warfarin, vitamin K1 (VK1), and menaquinone-4 (MK-4) concentrations were determined in 37 Japanese pediatric patients. The patients with CYP4F2 variant alleles C/T and T/T scored significantly lower values for the warfarin sensitivity index (INR/Cpss) and had significantly higher plasma concentrations of MK-4 than patients with the CYP4F2 allele C/C.
View Article and Find Full Text PDFScand J Urol Nephrol
October 1999
We report a case of anorchia in conjunction with isolated idiopathic hypogonadotropic hypogonadism. Plasma levels of LH, FSH, TSH and testosterone were abnormally low. Administration of human chorionic gonadotropin caused no increase in plasma testosterone, and injection of luteinizing hormone-releasing hormone resulted in no change in plasma gonadotropins.
View Article and Find Full Text PDFTo elucidate the effect of decreased amounts of collagen on prostatic growth, beta-aminopropionitrile, one of the agents that selectively inhibit collagen formation, was administered, with or without exogenous androgen and/or hypophysectomy, to rats of varying ages. The weight of the ventral prostate and the collagen content and the ratio of type III to type I collagen in the ventral prostate were examined. Administration of beta-aminopropionitrile, with or without exogenous androgen, reduced the collagen content in the ventral prostate in any age groups, but increased the weight of the ventral prostate only in young rats.
View Article and Find Full Text PDFInt Urol Nephrol
October 1996
A boy was found to have bilateral anophthalmia at birth. General health examination revealed cryptorchidism and micropenis. Physical and mental retardation in addition to epilepsy were observed.
View Article and Find Full Text PDFEighteen previously untreated patients with metastatic carcinoma of the prostate were treated with LHRH analogue. They were divided into 3 groups according to the degree of glandular differentiation. In all groups, a transient rise of PAP and PSA was observed after the LH and testosterone surge.
View Article and Find Full Text PDFInt Urol Nephrol
August 1995
We report here on two patients with kidney allografts who had hepatitis and duodenal ulcer caused by cytomegalovirus. In one case, hepatosplenomegaly and jaundice appeared after high fever lasting for ten days. Laboratory examinations showed liver dysfunction and lymphocytosis with atypical forms.
View Article and Find Full Text PDFThe purpose of this investigation was to assess whether the phentolamine test is able to predict blood pressure fluctuations during operations on patients with pheochromocytoma. We administered 5 mg phentolamine intravenously to 11 patients with pheochromocytoma and 6 patients with essential hypertension, pretreated with alpha-adrenoceptor antagonists. Plasma concentrations of epinephrine and norepinephrine were determined before and after phentolamine administration, and blood pressure was measured repeatedly.
View Article and Find Full Text PDFWe report a case of pericentric inversion of chromosome 9 associated with Sertoli-cell-only tubule. The literature is reviewed, and the hormonal profile and testicular histology are discussed.
View Article and Find Full Text PDFNerve conduction block by high-frequency stimulus has been used as a method to modulate the contractile force of skeletal muscles. This paper describes the effect of block stimulus on the modulation of urethral closure pressure in dogs. Tetanic stimulus was applied through a pair of electrodes wrapped about the bilateral pudendal nerves and high-frequency stimulus was superimposed through another pair of electrodes wrapped about 1 cm distalward along the nerves.
View Article and Find Full Text PDFHormonal profiles and testicular histology were studied in two patients with Down's syndrome with unilateral testicular tumor. Plasma levels of LH and FSH were elevated above normal ranges in both cases. In case 1, plasma testosterone level was abnormally low, but prolactin level in plasma was within the normal range.
View Article and Find Full Text PDFA 37-year-old man with membranous lipodystrophy (Nasu's disease) was urodynamically studied, to elucidate his urinary incontinence. Although medication failed to improve this unfavorable condition, urodynamic assessment of this patient clearly demonstrated the existence of an uninhibited overactive bladder.
View Article and Find Full Text PDFNerve conduction velocities and hair concentrations of trace elements were studied in 19 male patients with chronic renal failure undergoing haemodialysis. Both motor and sensory nerve conduction velocities were significantly lower in haemodialysis patients as compared to controls (p < 0.001).
View Article and Find Full Text PDFElectrical pelvic floor stimulation employing a portable functional electrical stimulation system with percutaneously indwelling electrodes was carried out to improve detrusor urinary incontinence. Cyclic stimulation using negative going pulse trains of 20 Hz was applied 3 to 6 times daily to the bilateral pudendal nerves distributing to the pelvic floor muscles for the purpose of strengthening these muscles, including the urethral sphincter, and simultaneously, suppressing detrusor overactivity and increasing cystometric capacity. Electrical training for 4-8 weeks resulted in an improvement of urinary incontinence in five of six patients.
View Article and Find Full Text PDFA new method of quantitative analysis of bone metastasis in prostate cancer is described. By using a variance-dependent filter and a smoothing filter, the increased uptake lesions were distinctly demonstrated on the bone scintigraphy. The images were divided into several areas and analyzed.
View Article and Find Full Text PDFInt Urol Nephrol
February 1994
We report a case of non-Hodgkin lymphoma with CT showing a single, bulky, and round retroperitoneal mass mimicking primary retroperitoneal tumours or metastatic lymph node. On MRI, the tumour was presumed originating from lymph nodes but we could not judge whether the tumour was due to lymphoma or metastasis.
View Article and Find Full Text PDFTwenty-eight patients who had been treated with ureterosigmoidostomy after radical cystectomy were examined with special reference to anal incontinence. In the present series, 17 out of 28 patients (60.7%) had daytime and/or nighttime anal incontinence.
View Article and Find Full Text PDFSix female patients with radiation cystitis, induced by previous pelvic radiation to uterus cancer, were treated with hyperbaric oxygenation (30-35% of oxygen concentration at 2 atmospheric absolute pressures for 90-120 min daily from 20 to 61 days with the average of 45 +/- 7 days, mean +/- standard error). Except in 1 patient symptoms and cystoscopic findings were improved. No side effects were found.
View Article and Find Full Text PDFThe effect of terodiline was investigated in 17 children with nocturnal enuresis. Twelve of them were evaluated urodynamically before treatment and 6 of these were proved to have detrusor instability with or without provocation. Terodiline in a daily dose of 12.
View Article and Find Full Text PDFWe report a case of autosomal translocation associated with azoospermia. The literature is reviewed, and hormone condition and testicular histology are discussed.
View Article and Find Full Text PDFKitasato Arch Exp Med
April 1991
The quality of 14 lots of acellular pertussis-diphtheria-tetanus (AC-PDT) vaccines manufactured by the Kitasato Institute during the period 1987-1990 were investigated. The geometric means of HSU, LPU, and BWDU were 0.078, 0.
View Article and Find Full Text PDFThe protective activity of acellular pertussis vaccine was comparable to that of whole cell vaccine against intracerebral and aerosol infection with Bordetella pertussis in mice. Suckling mice, six to 10 days old, born of mothers immunized with acellular or whole cell pertussis vaccine were challenged with an aerosol of B pertussis strain 18323, and body weight, death, leukocytosis, and viable counts in the lungs were monitored. Protective activity was transferred from mother mice to their offspring through milk and placenta (yolk sac), with substantially greater protection being transferred through the mammary gland.
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