Definition of Synovial Mesenchymal Stem Cells for Meniscus Regeneration by the Mechanism of Action and General Amp1200 Gene Expression.

The quality control (QC) of pharmaceutical-grade cell-therapy products, such as mesenchymal stem cells (MSCs), is challenging. Attempts to develop such products have been hampered by difficulties defining cell-type-specific characteristics and therapeutic mechanisms of action (MoAs). Although we have developed a cell therapy product, FF-31501, consisting of human synovial MSCs (SyMSCs), it was difficult to find specific markers for SyMSCs and to define the cells separately from other MSCs.

[Evaluation of AEC Consistency in Digital X-ray Imaging Systems].

The Japan Network for Research and Information on Medical Exposures (J-RIME) established the diagnostic reference level (DRL) and is advancing optimization of radiation protection. We believe that the difference in the imaging dose between facilities may be due to the fact that automatic exposure control (AEC) adjustment is not unified among manufacturers. The consistency of AEC is specified in JIS 4751-2-54, but it is not applicable to digital X-ray imaging systems because it is for optical density of analog X-ray imaging systems.

Bioresorbable Bone Graft Composed of an RGD-Enriched Recombinant Human Collagen Polypeptide Induced Neovascularization and Regeneration of Mature Bone Tissue.

Bone graft materials provide a scaffold for migrating cells for bone regeneration. One of the major challenges is to support adequate neovascularization in the graft materials and bone tissue. Vascular endothelial cells have been shown to recognize the integrin-binding Arg-Gly-Asp (RGD) sequence in natural extracellular matrix (ECM) molecules.

Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells.

To develop a novel intestinal drug absorption system using intestinal epithelial cells derived from human induced pluripotent stem (iPS) cells, the cells must possess sufficient pharmacokinetic functions. However, the CYP3A4/5 activities of human iPS cell-derived small intestinal epithelial cells prepared using conventional differentiation methods is low. Further, studies of the CYP3A4/5 activities of human iPS-derived and primary small intestinal cells are not available.

[Effect of Interspaces of Anti-scatter Grid on the Image Improvement Factor].

The standard general purpose of anti-scatter girds: JIS Z 4910: 2015 (IEC 60627: 2013) has been revised, with the new addition of an image improvement factor (Q) to the physical characteristic. Using aluminum (Al) and fiber-interspaced anti-scatter grids; we studied the meaning of Q by calculating each of the physical characteristics and assessing the image. The experimental method was based on JIS Z 4910: 2015.

[Development of a simple measurement system for routine management of X-ray equipment].

Routine management of X-ray equipment is critically important, but due to the high cost of commercial management systems it is currently not practical to deploy this valuable instrumentation at every clinical facility. This led us to develop a simple measurement system for routine management purposes that can be deployed for around ¥100 thousand in materials. The system consists of an X-ray output meter, a clamp-type X-ray tube current meter (clamp meter), and a digital oscilloscope.

[Characteristics of a new non-invasive x-ray output analyzer].

The X-ray systems study group used the Victoreen NERO mAx model 8000, a new non-invasive X-ray output analyzer, to measure the tube voltage, tube voltage waveform, tube current, and irradiation time for conditions corresponding to general radiography and mammography. The measurement results were then compared with those obtained using a conventional invasive measuring instrument. The peak values of the tube voltage measured by the NERO mAx and the invasive measuring instrument were compared.