Investigation of Bioequivalence Between Brand-name and Generic Irinotecan Products.

Background/aim: To investigate bioequivalence among generic and brand-name irinotecan products.

Materials And Methods: Products of Yakult and Daiichi-Sankyo (brand-name products), Sandoz, Nippon Kayaku, Taiho, and Sawai were compared with respect to their composition and antitumor activity.

Results: High-performance liquid chromatography demonstrated that related substances were within the acceptable range.