Publications by authors named "Izumi Irita"
Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE.
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- The Wnt/β-catenin signaling pathway is implicated in glucocorticoid-induced osteoporosis (GIOP), and previous studies suggested that inhibiting sclerostin could provide a treatment option.
- The study aimed to evaluate the effectiveness of romosozumab (ROMO), compared to denosumab (DMAb) and bisphosphonates (BP), in increasing bone mineral density (BMD) in patients with rheumatic diseases undergoing glucocorticoid therapy.
- Results showed that ROMO significantly improved lumbar spine BMD after 12 months, indicating that it is a promising treatment for patients with GIOP.