Publications by authors named "Izaskun Itxaso"
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation.
Joshua Adekunle Babalola Magdalena Lang Meekha George Anika Stracke Carmen Tam-Amersdorfer Izaskun Itxaso
Brain Res
November 2023
Article Synopsis
- Defective clearance of amyloid-β (Aβ) and inflammation contribute significantly to Alzheimer's disease (AD), with problems in transporting Aβ across the blood-brain barrier leading to plaque formation.
- A study using porcine brain cells and murine hippocampal cultures showed that the antioxidant astaxanthin (ASX) improved the clearance of misfolded proteins and altered Aβ processing by promoting autophagy and enhancing specific transporters.
- ASX also demonstrated anti-inflammatory properties by decreasing inflammatory cytokines and shifting microglial cells from a pro-inflammatory state (M1) to a protective state (M2), suggesting its potential as a treatment for AD-related issues.