Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets.

Objective: To investigate the influence of the Trp64Arg polymorphism in the beta 3-adrenoreceptor gene on adipocytokines, insulin resistance and weight loss secondary to a low fat versus a low carbohydrate diet.

Methods: A population of 193 obese patients was analyzed. A nutritional evaluation was performed at the beginning and at the end of a 2-month period in which subjects received 1 of 2 hypocaloric diets.

[Effects of a diet with products in texture modified diets in elderly ambulatory patients].

Background: Decrease in the capacity to deglution solids and liquids is a problem in many people, this problem decreases quality of life. The main objective of our work was to evaluate the influence in elderly ambulatory patients with dysphagia of a texture modified diet ready to use on nutritional parameters and quality of life.

Methods: We enrolled 29 patients from Nutrition Department with dysphagia and an age over 70 years.

Relation of resistin levels with cardiovascular risk factors and insulin resistance in non-diabetes obese patients.

Background: The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors.

Subjects: A population of 213 obese was analyzed. A complete nutritional and biochemical evaluation was performed.

[The effects of a low-fat versus a low carbohydrate diet in obese adults].

Background And Objective: The aim of our study was to compare the effect of a high fat and a high protein diet vs a fat restricted diet on weight loss in obese patients.

Subjects And Methods: A population of 74 obesity non diabetic outpatients was analyzed in a prospective way. Patients were randomly allocated to two groups: a) diet I (low fat diet: 1500kcal/day, 52% carbohydrates, 20% proteins, 27% fats) with a distribution of fats and b) diet II (high fat and high protein diet: 1507kcal/day, 38% carbohydrates, 26% proteins, 36% fats).

Circulating visfatin in obese non-diabetic patients in relation to cardiovascular risk factors, insulin resistance, and adipocytokines: a contradictory piece of the puzzle.

Objective: Obesity and insulin resistance are associated with cardiovascular risk factors. The aim of the present study was to explore the relation of circulating visfatin to insulin resistance, cardiovascular risk factors, anthropometry, and adipocytokines in obese patients without diabetes mellitus.

Methods: A population of 228 obese non-diabetic outpatients was analyzed in a prospective way.

[Arginine enhanced enteral nutrition, effect on blood inflammatory markers in head and neck cancer patients].

Background And Objective: Although immune dysfunction in cancer patients could be multifactorial, the immune system may be modulated by specific nutritional substrates, such as arginine. The aim of our study was to evaluate the effect of enteral nutrition supplemented with a high dose of arginine on c-reactive protein (CRP), interleukin 6 (IL6) and tumoral necrosis factor (TNF alpha) in surgical head and neck cancer patients.

Subjects And Methods: At surgery, patients were randomly allocated to two groups: (a) enteral diet supplements with arginine (group I, n=18); (b) isocaloric, isonitrogenous enteral formula (group II, n=23).

Relation of visfatin to cardiovascular risk factors and adipocytokines in patients with impaired fasting glucose.

Objective: The discovery of visfatin has great potential to significantly enhance our understanding of impaired fasting glucose and diabetes mellitus. The aim of the present study was to explore the relation of visfatin concentrations to cardiovascular risk factors and serum adipocytokine concentrations in patients with impaired fasting glucose.

Methods: A sample of 55 patients with impaired fasting glucose was analyzed in a prospective way.

Clinical results and nutritional consequences of biliopancreatic diversion: three years of follow-up.

Background: Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The aim of our work was to describe clinical results and nutritional complications in morbidly obese patients with biliopancreatic diversion.

Methods: We have analyzed a consecutive series of 64 patients who have been followed up for 3 years after undergoing open biliopancreatic diversion by the Scopinaro technique.

Influence of G308A promoter variant of tumor necrosis factor-alpha gene on insulin resistance and weight loss secondary to two hypocaloric diets: a randomized clinical trial.

Background And Aims: The aim of our study was to investigate the influence of G-308A promoter variant in the TNF-alpha gene on insulin resistance and weight loss secondary to two hypocaloric diets.

Methods: Two hundred and three obese, nondiabetic patients were analyzed. Before and after 2 months of two hypocaloric diets, a nutritional evaluation and a blood analysis were performed.

Influence of visfatin on histopathological changes of non-alcoholic fatty liver disease.

Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. The aim of the present study was to explore the relation of visfatin with underlying histopathological changes of NAFLD patients.

Subjects: A population of 55 NAFLD patients was analyzed in a cross-sectional study.

Relation of Trp64Arg polymorphism of beta3-adrenoreceptor gene with cardiovascular risk factors in presurgical morbidly obese patients.

Background: Genetic background of presurgical morbidly obese patients may have an influence on follow-up and outcome. A genetic variant is the Trp64Arg missense mutation in the beta3-adrenoreceptor (beta3-AR) gene.

Methods: We investigated the influence of the Trp64Arg polymorphism in the beta3-AR gene on adipocytokines and cardiovascular risk factors in presurgical morbidly obese patients.

Modulation of insulin concentrations and metabolic parameters in obese patients by -55CT polymorphism of the UCP3 gene secondary to two hypocaloric diets.

Decreased expression or function of UCP3 could reduce energy expenditure and increase the storage of energy. The aim of our study was to investigate the influence of -55CT polymorphism of the UCP3 gene on insulin concentrations and metabolic parameters secondary to two hypocaloric diets in obese patients. A population of 131 obese (body mass index >30), nondiabetic outpatients was analyzed in a prospective way.

A randomized clinical trial with two enteral diabetes-specific supplements in patients with diabetes mellitus type 2: metabolic effects.

The aim of this study was to investigate whether two specific diabetes enteral formulas could improve nutritional as well as metabolic parameters in elderly patients with diabetes mellitus type 2. A population of 30 elderly patients with diabetes mellitus type 2 with recent weight loss was recruited. At basal time diabetic patients were asked to consume randomly two cans per day of two different specially designed high monounsaturated fatty acid diabetes-specific supplement: one with 49.

Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial.

Objective: A transition G to A at codon 54 of FABP2 was associated with high insulin resistance and different dietary response. The aim of our study was to investigate the influence of this polymorphism on weight loss and metabolic changes secondary to two hypocaloric diets.

Subjects And Methods: A sample of 204 obesity patients was analyzed.

A randomized clinical trial with two omega 3 fatty acid enhanced oral supplements in head and neck cancer ambulatory patients.

The aim of our study was to investigate whether oral ambulatory nutrition of post surgical head and neck cancer patients with recent weight loss, using two different omega 3 fatty acids enhanced diets could improve nutritional variables as well as clinical outcome. A sample of 65 ambulatory post surgical patients with oral and laryngeal cancer and recent weight loss was enrolled. At Hospital discharge post surgical head and neck cancer patients were asked to consume two cans per day of either a specially designed omega 3 fatty acid enhanced supplement with a high ratio of omega3/omega6 (I) or a omega 3 fatty acid enhanced supplement with a low ratio of omega3/omega6 (II).

Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.

This is a descriptive study in diabetic patients. Mutant type patient (39%) (Lys656/Asn656 or Asn656/Asn656) group had higher fat mass, HOMA, CRP and leptin than wild type. Adiponectin levels were lower in mutant type group than wild type (61%) (Lys656/Lys656).

Relation of Trp64Arg polymorphism of beta 3-adrenergic receptor gene to adipocytokines and fat distribution in obese patients.

Background/aim: Obesity has multiple causes and is determined by the interaction between genetic and environmental factors. A genetic factor is a (Trp64Arg) missense mutation in the beta 3-adrenergic receptor. The aim of our study was to investigate the influence of Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on weight, adipocytokines, insulin resistance, and fat distribution in obese patients.

Influence of G308A polymorphism of tumor necrosis factor alpha gene on surgical results of biliopancreatic diversion.

Background: Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate G308A polymorphism of the tumor necrosis factor (TNF) alpha gene on outcomes 1 year after biliopancreatic diversion.

Methods: A sample of 41 morbidly obese patients (body mass index > 40 kg/m(2)) were operated on.

Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial.

Background: Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin-resistant.

Objective: The aim of our study was to investigate the influence of Lys656Asn polymorphism in the LEPR gene on leptin response secondary to a low fat versus a low carbohydrate diet in obese patients.

Design: A population of 78 obesity patients was enrolled.

Influence of -55CT polymorphism of UCP3 gene on surgical results of biliopancreatic diversion.

Background: Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate the UCP3 promotor (-55C-->T) polymorphism outcomes 1 year after biliopancreatic diversion in morbidly obese patients.

Methods: A sample of 40 morbidly obese patients (BMI >40 kg/m(2)) were operated.

[Evaluation of two methods for correcting the impact factor using the investigation done at the "Del Río Hortega" University Hospital (1999-2004) as the data source].

Background And Objective: To adjust the Impact Factor (IF) provided by the Institute for Scientific Information (ISI) is necessary for improving bibliometric analysis among the various areas of knowledge. Our objective was to evaluate two parameters (the maximum and the median value of each subject area) for IF adjustment using the original (not corrected) IF as the reference method in a tertiary hospital biomedical investigation model.

Material And Method: We retrieved articles from Hospital Universitario "Del Río Hortega" from Valladolid (Spain) for the period 1999-2004 as data source.

Influence of Lys656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients.

Background: Alterations of the normal leptin receptor (LEPR) gene may be involved in the development of obesity. Leptin has been shown to be able to modulate insulin secretion. Different polymorphisms in the LEPR gene have been studied, albeit with unclear results.

The effects of two different hypocaloric diets on glucagon-like peptide 1 in obese adults, relation with insulin response after weight loss.

Objective: Few studies have investigated the effect of type of diets on GLP-1 concentrations. The aim of this study was to compare the effect of two diets on circulating GLP-1 levels and the relation with insulin response after weight loss.

Methods: A population of 118 obese patients were analyzed.

Effects of lifestyle modification on adipocytokine levels in obese patients.

Objective: Adipose tissue is considered an active secretory organ of adipocytokines. The principal aim of our study was to examine the changes in adipocytokines levels after weigth reduction in obese patients.

Materials And Methods: A population of 126 obese (body mass index > 30) non-diabetic outpatients was analyzed in a prospective way.

Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene.

Decreased expression or function of UCP3 (uncoupling protein 3) could reduce energy expenditure and increase the storage of energy as fat. Some studies have pointed to a role of UCP3 in the regulation of whole body energy homeostasis, diet induced obesity, and regulation of lipids as metabolic substrates. The C/C genotype of a polymorphism in the UCP3 promoter (-55C-->T) is associated with an increased expression of UCP3 mRNA in muscle.