Publications by authors named "Izad-Yar D Rasheed"
Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy.
J Cereb Blood Flow Metab
August 2023
Dynamic cerebral autoregulation (dCA) can be derived from spontaneous oscillations in arterial blood pressure (ABP) and cerebral blood flow (CBF). Transcranial Doppler (TCD) measures CBF-velocity and is commonly used to assess dCA. Diffuse correlation spectroscopy (DCS) is a promising optical technique for non-invasive CBF monitoring, so here we aimed to validate DCS as a tool for quantifying dCA.
View Article and Find Full Text PDFEnergy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity.
View Article and Find Full Text PDFArticle Synopsis
- - HIV-1 infection in the central nervous system (CNS) can lead to reduced blood flow and cognitive decline, resembling accelerated aging in terms of brain blood vessel structure.
- - Researchers used a specific type of genetically modified mice (HIV-1 Tat-transgenic) and control mice to analyze brain blood vessel density and red blood cell movement over different time periods.
- - Findings show that HIV-1 Tat-transgenic mice experienced significant decreases in capillary length and uneven red blood cell velocity, suggesting that such changes might contribute to cognitive issues in older HIV-positive individuals.