Current state of knowledge on oral anticoagulant reversal using procoagulant factors.

Objective: To discuss current trends and challenges in the use of procoagulants for treating bleeding caused by use of oral anticoagulants.

Data Sources: Literature searches of PubMed (MEDLINE), Google, and Medscape were conducted in February 2013. There were no date limitations.

[Prenatal diagnosis of fetal chromosomal aneuploidies using quantitative fluorescent PCR (QF-PCR)].

The trisomy of the 21 chromosomes is one of the most important chromosomal anomalies and is responsible for Down syndrome. It persists in Poland in 1/700 birth. The risk of childbirth with Down syndrome grows with age, especially in women after 35 years old.

Predictive value of HPV DNA in lymph nodes in surgically treated cervical carcinoma patients--a prospective study.

Objective: High-risk types of HPV are etiological factors in cervical cancer. Lymph node involvement in cervical cancer patients reduces 5-year survival rates by 25-60%. However, the influence on survival of HPV DNA positivity in histopathologically negative lymph nodes remains unresolved.

[Analysis of correlation between HPV DNA lymph node presence and pathologic parameters of primary tumour in cervical carcinoma patients treated surgically].

Young-age sexual activity, multiple sexual partners, number of pregnancies, smoking and human papilliomavirus (HPV) infections are factors commonly considered as promoters of cervical tumorogenesis. Cervical carcinoma patients' prognosis correlates significantly with staging (according to FIGO classification). In early stages lymph-node involvement is considered as the most important prognostic factor.

[HPV 16 DNA occurrence in lymph nodes of patients with cervical carcinoma].

Objectives: We estimated the occurrence of DNA HPV 16 presence in lymph nodes of 25 patients undergoing abdominal operation for cervical carcinoma.

Materials And Methods: The presence of HPV 16 DNA was detected during the preoperative diagnosis procedure by the PCR method.

Results: According to the histopathological examination, metastases in the lymph nodes were present in material from two patients.

[The incidence of human papilloma virus (HPV) DNA in patients with cervical carcinoma from Gdansk region].

Objectives: We have estimated the incidence of human papilloma virus (HPV) DNA in cervical smears of patients with cervical carcinoma, treated in 1997-1998 at the II Department of Obstetrics and Gynecology, Medical University of Gdańsk, Poland.

Materials And Methods: We have examined 107 patients suffering from cervical cancer. The HPV DNA was detected with the polymerase chain reaction (PCR) method using two primer pairs located in the E6, E7 open reading frames.

Human papillomavirus type 16 status in cervical carcinoma cell DNA assayed by multiplex PCR.

Integration of human papillomavirus (HPV) DNA into host genome occurs early in cancer development and is probably an important event in malignant transformation of cervical cancer. The HPV genome integration usually disrupts E2 gene open reading frames. It results in the lack of E2 gene suppressor of the synthesis of E6 and E7 products which, in turn, leads to the overexpression of E6 and E7 genes.