Publications by authors named "Izabela Szpregiel"
Article Synopsis
- * Research shows that psilocybin acts on 5-HT2A receptors, leading to increased levels of the neurotransmitter glutamate (GLU) in areas of the brain associated with mood regulation.
- * By enhancing glutamatergic activity, psilocybin may help promote neuroplasticity and has therapeutic potential for treating depression and other neurological disorders.
Context: Juxtacrine (contact-dependent) communication between the cells of seminiferous epithelium mediated by Notch signalling is of importance for the proper course of spermatogenesis in mammals.
Aims: The present study was designed to evaluate the role of follicle-stimulating hormone (FSH) in the regulation of Notch signalling in rodent seminiferous epithelium.
Methods: We explored the effects (1) of pharmacological inhibition of the hypothalamus-pituitary-gonadal (HPG) axis and FSH replacement in pubertal rats, and (2) of photoinhibition of HPG axis followed by FSH substitution in seasonally breeding rodents, bank voles, on Notch pathway activity.
One of the major roles of glutamic acid (Glu) is to serve as an excitatory neurotransmitter within the central nervous system (CNS). This amino acid influences the activity of several brain areas, including the thalamus, brainstem, spinal cord, basal ganglia, and pons. Catecholamines (CAs) are synthesized in the brain and adrenal medulla and by some sympathetic nerve fibers.
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- Glutamic acid decarboxylase (GAD) is an enzyme that converts glutamic acid (Glu), an excitatory neurotransmitter, into GABA, the main inhibitory neurotransmitter, helping to maintain balance in the nervous system.
- The study found varying concentrations of GAD in different motivational brain structures in rabbits, with the highest levels in the hypothalamus, suggesting GAD's significant role in stress response.
- Results indicated that changes in GAD concentration were more influenced by blocking glutamate receptors than by stress, highlighting the need for further research on the Glu-GAD-GABA system in stress modulation and homeostasis.