New N4-Donor Ligands as Supramolecular Guests for DNA and RNA: Synthesis, Structural Characterization, In Silico, Spectrophotometric and Antimicrobial Studies.

The present work reports the synthesis of new N4-donor compounds carrying p-xylyl spacers in their structure. Different Schiff base aliphatic N-donors were obtained synthetically and subsequently evaluated for their ability to interact with two models of nucleic acids: calf-thymus DNA (CT-DNA) and the RNA from yeast Saccharomyces cerevisiae (herein simply indicated as RNA). In more detail, by condensing p-xylylenediamine and a series of aldehydes, we obtained the following Schiff base ligands: 2-thiazolecarboxaldehyde (), pyridine-2-carboxaldehyde (), 5-methylisoxazole-3-carboxaldehyde (), 1-methyl-2-imidazolecarboxaldehyde (), and quinoline-2-carboxaldehyde ().

Synthesis and Characterization of Lanthanide Metal Ion Complexes of New Polydentate Hydrazone Schiff Base Ligand.

The new homodinuclear complexes of the general formula [Ln(NO)] (where is newly synthesized 2-((2-(benzoxazol-2-yl)-2-methylhydrazono)methyl)phenol and Ln = Sm (), Eu (), Tb (, ), Dy (), Ho (), Er (), Tm (), Yb ()), have been synthesized from the lanthanide(III) nitrates with the polydentate hydrazone Schiff base ligand. The flexibility of this unsymmetrical Schiff base ligand containing NO binding moiety, attractive for lanthanide metal ions, allowed for a self-assembly of these complexes. The compounds were characterized by spectroscopic data (ESI-MS, IR, UV/Vis, luminescence) and by the X-ray structure determination of the single crystals, all of which appeared to be different solvents.

Synthesis and Spectroscopic Investigations of Schiff Base Ligand and Its Bimetallic Ag(I) Complex as DNA and BSA Binders.

Generation of well-defined potential metallotherapeutics for cancer treatment, one of the most population-threatening diseases, is challenging and an active area of modern research in view of their unique properties and thus multiple possible pathways of action in cells. Specifically, Schiff base ligands were recognized as very promising building blocks for the construction of stable and active complexes of numerous geometries and topologies. Incorporation of Ag(I) ions allows for the formation of flat complexes with potential unoccupied coordination sites, thus giving rise to specific interactions between the metallotherapeutic and biomolecule of interest.

Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect.

Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine ( complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies.

Disordered structure of propane-1,2-diaminium dichloride.

In the title compound, C(3)H(12)N(2) (2+)·2Cl(-), the cations are disordered over two well resolved positions in a 0.525 (13):0.475 (13) ratio.

N,N'-bis(2-hydroxybenzylidene)pentane-1,5-diamine.

In the title potential O,N,N',O'-tetradentate Schiff base ligand {systematic name: 2,2'-[pentane-1,5-diylbis(nitrilomethylidyne)]diphenol}, C(19)H(22)N(2)O(2), the mutual orientation of the three planar fragments determines the conformation of the molecule. The dihedral angles between the planes of the two salicylidene groups and the plane of the central extended pentane chain are 78.4 (2) and 62.

Cadaverinium dichloride: a case of centro-non-centrosymmetric ambiguity.

In the title salt, also known as pentane-1,5-diammonium dichloride, C(5)H(16)N(2)(2+)x2Cl(-), the cation exists in an ideal fully extended conformation and lies on a mirror plane in the space group Pbam. In the crystal structure, layers of cations are hydrogen bonded with Cl(-) anions, which occupy the space between the layers. This kind of packing leads to a short unit-cell parameter of 4.

Redetermination of sperminium tetrachloride.

In the title compound, 1,5,10,14-tetraazoniatetradecane tetrachloride, C(10)H(30)N(4)(4+).4Cl(-), the sperminium tetracation lies on a centre of symmetry. The two central C-N-C-C torsion angles are gauche and of opposite signs, and all the other torsion angles are trans.