Publications by authors named "Izabela Kasenberg"
Baseline Proteinuria and Serum Creatinine Concentration as Clinical Predictors of Complete Renal Response in Patients with Lupus Nephritis: A Single-Center Experience.
Int J Environ Res Public Health
November 2022
Article Synopsis
- The study aimed to identify strong predictors of complete renal response (CRR) in lupus nephritis patients over 36 months by analyzing a cohort of patients who had kidney biopsies from 2010 to 2020.
- The research found that 63.2% of the 57 patients achieved CRR, defined by a significant drop in urinary protein-to-creatinine ratio (UPCR) below 0.50 g/g.
- Key predictors of CRR included initial UPCR and estimated glomerular filtration rate (eGFR), with significant statistical values indicating their relevance in renal recovery.
Background: Lupus nephropathy (LN) occurs in approximately 50% of patients with systemic lupus erythematosus (SLE), and 20% of them will eventually progress into end-stage renal disease (ESRD). A clinical tool predicting remission of proteinuria might be of utmost importance. In our work, we focused on predicting the chance of complete remission achievement in LN patients, using artificial intelligence models, especially an artificial neural network, called the multi-layer perceptron.
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