Quantitative assessment of radioactivity losses in the administration of therapeutic doses of [177Lu]Lu-DOTA-TATE and [90Y]Y-DOTA-TATE.

Background: Therapeutic radiopharmaceuticals [¹⁷⁷Lu]Lu-DOTA-TATE and [⁹⁰Y]Y-DOTA-TATE are used in peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. One of the factors determining the efficacy of such therapy is administering the radiopharmaceutical dose to the patients in a way consistent with treatment planning. This paper evaluates the loss of [¹⁷⁷Lu]Lu-DOTA-TATE and [⁹⁰Y]Y-DOTA-TATE and their mixed doses during the administration to the patient either by direct infusion or by gravity method.

Cu Production Capabilities: A Mini Review.

Is the Cu production worldwide feasible for expanding preclinical and clinical studies? How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for personalized therapies? This review looks at the different production routes, including the accelerator- and reactor-based ones, providing a comprehensive overview of the actual Cu supply, with brief insight into its use in non-clinical and clinical studies. In addition to the most often explored nuclear reactions, this work focuses on the Cu separation and purification techniques, as well as the target material recovery procedures that are mandatory for the economic sustainability of the production cycle. The quality aspects, such as radiochemical, chemical, and radionuclidic purity, with particular attention to the coproduction of the counterpart Cu, are also taken into account, with detailed comparisons among the different production routes.

Improved procedures of Sc(OH)3 precipitation and UTEVA extraction for 44Sc separation.

Background: 44Sc is becoming attractive as a PET radionuclide due to its decay characteristics. It can be produced from 44Ca present in natural calcium with 2.08% abundance.

Manufacturing and characterization of molybdenum pellets used as targets for Tc production in cyclotron.

The method of Mo metallic target preparation for production of Tc by proton irradiation in Mo(p,2n)Tc reaction was demonstrated. For this purpose, pressing of molybdenum powder into pellets and their subsequent sintering in reductive atmosphere were applied. The influence of parameters such as molybdenum mass and time of both pressing and sintering on the Mo target durability was investigated.

Thermal diffusion of 57Co into rhodium matrix as a second step in preparing Mössbauer sources.

Thermal diffusion of (57)Co into rhodium matrix was studied. The diffusion degree was evaluated by Mössbauer spectroscopy with the use of α-Fe absorber. The influence of different annealing conditions was investigated.

Electrodeposition of carrier-free 57Co on rhodium as an approach to the preparation of Mössbauer sources.

Electrodeposition of carrier-free (57)Co on a rhodium matrix as the first step of preparing Mössbauer sources was studied. To optimize the plating parameters, the influences of current density, volume and pH of the electrolyte solution, shape, thickness, and surface area of the rhodium cathode, mode of cathode pretreatment, concentration of (57)Co and duration of electrolysis were investigated.