Publications by authors named "Izabel Regina Fischer Rubira Bullen"

Diagnosing dental caries poses a significant challenge in dentistry, necessitating precise and early detection for effective management. This study utilizes Self-Supervised Learning (SSL) tasks to improve the classification of dental caries in Cone Beam Computed Tomography (CBCT) images, employing the International Caries Detection and Assessment System (ICDAS). Faced with the challenge of scarce annotated medical images, our research employs SSL to utilize unlabeled data, thereby improving model performance.

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Objectives: Despite phototherapy (in the form of photodynamic therapy (PDT)-mediated oxidative stress) being utilized in the management of oral potentially malignant disorders (OPMDs), the evidence of certainty remains unclear. Hence, this systematic review and meta-analysis (PROSPERO # CRD42021218748) is aimed to evaluate the clinical efficacy of PDT-induced oxidative stress in OPMDs METHODS: PubMed, Embase, Web of Science, Scopus, and Cochrane Library databases were searched without restriction of language or year of publication. In addition, gray literature was searched and a manual search was performed.

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Background: The IC may cause reabsorption of adjacent teeth; therefore detailed assessment of its position would enhance decision-making in the clinical workflow. The objective was to compare cone-beam computed tomography (CBCT) and panoramic radiography (PR) in assessing the position of the impacted upper canine (IC) and root resorption of adjacent teeth.

Material And Methods: Pubmed, EMBASE, Science Direct, Web of Science, and SCOPUS databases were searched for studies published before August 2023.

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Dental caries occurs from the interaction between oral bacteria and sugars, generating acids that damage teeth over time. The importance of X-ray images for detecting oral problems is undeniable in dentistry. With technological advances, it is feasible to identify these lesions using techniques such as deep learning, machine learning, and image processing.

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Objective:  Sickle cell disease (SCD) is a common inherited disease, and is characterized by a genetic modification that determines the production of a hemoglobin with altered morphology. This anatomical change of hemoglobin leads to vaso-occlusive disorders and premature hemolysis of the cell, causing chronic anemia and bone marrow hyperplasia due to increased hematopoietic demand. As a consequence, several skeletal changes are reported in the skull, spine, ribs, pelvis, femur, and metatarsals.

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Background: The aim of the present study was to compare the recurrence rates of solid multicystic ameloblastomas after segmental resection or marginal resection.

Material And Methods: PubMed, ScienceDirect, Web of Science, Scopus, Embase were searched for studies published up to July 2022. The gray literature was also searched.

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Background: This systematic review aimed to conduct a complete investigation of the demographic aspects, clinicopathological features, degrees of epithelial dysplasia, and malignant transformation rate of actinic cheilitis.

Methods: The study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered in the International Prospective Register of Systematic Reviews (CRD42020201254). A search without year and language restrictions was performed using PubMed/MEDLINE, Embase, Virtual Health Library, Scopus, Web of Science, and gray literature.

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Article Synopsis
  • The study aimed to find out how common orofacial changes are in people with sickle-cell disease (SCD) and to compare these findings with those from the general population.
  • A total of 28 studies were selected from 770 records, indicating significant issues like decreased bone density (57%), malocclusion (66%), and delayed tooth eruption (20%) in SCD patients.
  • The research noted a high risk of bias due to small sample sizes and a lack of comparisons between SCD patients and healthy individuals regarding these orofacial alterations.
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Purpose: The double coronoid process (DCP) is a very unusual feature in patient. The literature, which briefly describes just only one case. Being this a very unusual feature, the aim of the paper is to describe the finding, discuss the anatomic, radiological, and clinical characteristics of a DCP.

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Leukocyte and platelet-rich fibrin is known to contain high concentrations of growth factors and when associated with rhBMP-2, it may increase bone remodeling due to its osteoinductive property. The aim of this case is to report the outcome of surgical treatment of medication-related osteonecrosis of the jaw with prototype plate installation and the use of leukocyte and platelet-rich fibrin in association with rhBMP-2 in a 78-year-old female patient under therapy with alendronate. The present Studies describes that the combination of this treatment presented complete healing of osteonecrosis and represents a promising treatment option to be used for medication-related osteonecrosis of the jaw.

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Objective: The purpose was to describe whether there are field cancerization (FC) indicators in clinically normal mucosa opposite to primary oral squamous cell carcinoma (OSCC).

Methods: A search of the Cochrane Library, PubMed, Embase, Web of Science, Scopus, and Livivo databases was performed on June 12, 2022, which retrieved 152 records without duplicates. Studies that analyzed FC in biopsies in clinically normal tissue opposite to primary OSCC were included.

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The aim of this study was to use microscopic and molecular techniques to evaluate the effects of a single session of antimicrobial photodynamic therapy (aPDT) on the alveolar repair process after tooth extraction in rats. The study sample included 84 rats divided into four groups, as follows: a) Control - untreated socket; b) Laser - socket treated using photobiomodulation; c) TBO - socket treated with topic application of the photosensitizer agent, toluidine blue O (TBO); and d) aPDT - socket treated with TBO and laser irradiation. An additional rat was used for thermal mapping during socket irradiation.

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Article Synopsis
  • - The study aims to determine if cone beam computed tomography (CBCT) provides better diagnostic accuracy than panoramic radiography (PR) for predicting inferior alveolar nerve (IAN) exposure during lower third molar extractions.
  • - A meta-analysis was conducted using three eligible studies, revealing that CBCT demonstrated a high sensitivity of 95.1% and a specificity of 64.4%, while PR had a sensitivity of 73.9% and a notably low specificity of 24.8%.
  • - The findings suggest that while both imaging techniques can identify IAN exposure, CBCT is significantly more effective in predicting such exposure during dental surgeries, helping to mitigate risks of nerve injury.
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Objective: The aim of this study was to evaluate the accuracy of multislice computed tomography (MSCT) and cone beam computed tomography (CBCT) scanners in the assessment of trabecular bone microarchitecture by radiomorphometric analysis.

Methods: Eight dry human hemimandibles were selected and scanned by 4- and 128-MSCT, CBCT with different voxel sizes, and a computed microtomography (micro-CT). The images were spatially aligned, the axial slices were segmented using CTAn software (Skyscan, Konitch, Belgium), and 10 bone morphometric parameters were quantified.

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Article Synopsis
  • The study reviews different types of cone-beam computed tomography (CBCT) artifacts around dental implants and what causes them.
  • The research involved analyzing 9 studies from various databases between 2010 and 2020, focusing on 306 dental implants made of materials like titanium and zirconia.
  • Key artifacts identified include beam-hardening and streaking artifacts, with factors such as implant material, bone type, and imaging parameters affecting their occurrence, highlighting the importance of careful imaging protocols in dental implant procedures.
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Objective: Evaluate if automatic segmentation of mandibular three-dimensional (3D) models is reliable and accurate.

Materials And Methods: Eight dry mandibles with eight silica markers were scanned in the i-CAT Classic device (Imaging Sciences International). Automatic segmentation was performed using nine standard preset thresholds in the Dolphin software (Dolphin Imaging & Management Solutions).

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Article Synopsis
  • - The study aims to compare the effectiveness of limited vs large volume cone-beam computed tomography (CBCT) in identifying isthmuses in the apical root canals of mandibular molars.
  • - Forty mandibular molars were scanned using micro-CT to establish measurements, and two CBCT systems were tested for their ability to detect these features, with statistical analyses conducted to compare results.
  • - Both CBCT systems showed similar detection rates for isthmuses, but neither matched the performance of micro-CT, highlighting the usefulness of CBCT in endodontics despite its limitations.
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Objective: The objective of this study was to assess inflammatory cytologic alterations in the oral epithelium of patients on human immunodeficiency virus pre-exposure prophylaxis (PrEP).

Material And Methods: Epithelial cells from the buccal mucosa of 30 patients were collected by exfoliative cytology and were evaluated according to inflammatory cellular alterations: karyomegaly, bi- or multinucleation, karyopyknosis, karyorrhexis, perinuclear halo formation, metachromasia, cytoplasmic vacuolization, indistinct cytoplasmic border, keratinization, and atrophy. Epithelial cells were collected initially before PrEP onset (T1) and then after 30 days of PrEP use (T2).

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Objective: The aim of this study was to evaluate the posterior superior alveolar canal (PSAC) in patients with cleft lip and palate (CLP) as compared to patients with no cleft lip and palate (NC) using cone-beam computed tomography (CBCT).

Materials And Methods: This was a retrospective multicenter study based on two steps: (1) evaluating intra- and inter-calibration and (2) detecting the presence or absence of PSAC and its location, diameter, and anastomosis with anterior superior alveolar canal.

Results: A total of 300 patients were selected for the study, out of which 150 were categorized as CLP (75 men, 75 women; mean age: 29.

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Introduction: Isthmuses are reported as common anatomic complexities in teeth often associated with failures in endodontic treatment. They should be considered before starting treatment and a preoperative computed tomography scan (CT) may demonstrate these complexities.

Objective: To assess the diagnostic value of the highest resolution settings of a cone-beam CT (CBCT) system in identifying and measuring apical isthmuses, using micro-CT as reference.

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Objectives: The current dentistry scenario is showing an increase in the availability of cone-beam computed tomography (CBCT) in dental offices. Oral surgeons are using three-dimensional information as an additional tool to assess preoperative data for lower third molar (LTM) removal in moderate and high-risk cases of inferior alveolar nerve (IAN) injury diagnosed through the panoramic radiography (PR). The aim of this study is to identify whether CBCT examination reduces neurosensoric disturbances (ND) following the removal of the LTM when compared to PR.

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Background: Bovine bone grafts have been widely used in dentistry for guided tissue regeneration and can support new bone formation in direct contact with the graft. The aim of this study was to compare the morphometric and bone density changes after using two different bovine bone graft blocks in segmental osseous defects in the mandible of rabbits following different postoperative periods.

Material And Methods: Critical size segmental defects were surgically created bilaterally in the jaw of 18 rabbits.

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Objectives: This study investigated the association of congenital cervical vertebrae anomalies (CVA) with the prevalence of cleft lip and palate (CLP) specifying the most frequent associations.

Methods: A meta-analysis was based on the Preferred Reporting Items of Systematic reviews and Meta-Analyses guideline. A search of the PubMed, Embase, Web of Science, Science Direct, Scopus and Lilacs database was performed until March 2018.

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Article Synopsis
  • The study investigates the dosimetry of low-level laser therapy (LLLT) for treating and preventing oral mucositis (OM) in head and neck cancer patients undergoing radiation therapy, considering factors like tissue type and laser equipment.
  • A systematic review filtered through the PRISMA guidelines identified 7 relevant studies out of 130 records, encompassing 363 patients with a range of cancers affecting various oral sites.
  • Results indicate LLLT is effective across different parameters, but there's still no conclusive evidence on the optimal laser dosimetry, highlighting the need for more randomized clinical trials to clarify the best dosages for OM treatment and prevention.
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The foramen of Huschke (FH) is present in the early stages of the temporal bone tympanic portion development. The literature shows that FH may persist in adult individuals and several authors acknowledge its clinical importance, reporting being associated with the dissemination of diseases. Some authors believe that FH presents importance in archeology and forensic situations.

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