Publications by authors named "Izabel C N de Palmer Paixao"
Article Synopsis
- - The study focuses on evaluating new quinolone derivatives as potential antiviral agents against herpes simplex virus (HSV) due to the emergence of resistant strains.
- - In vitro tests showed that these compounds effectively inhibited HSV replication, particularly by suppressing ICP27 viral protein expression, with EC values ranging from 8 μM to 32 μM, and highlighted the importance of specific chemical structures for effectiveness.
- - While these new derivatives exhibited lower antiviral activity than acyclovir, they demonstrated unique mechanisms of action, warranting further pre-clinical research to develop these agents as alternative HSV treatments.
Article Synopsis
- Chikungunya virus (CHIKV) causes debilitating joint pain through Chikungunya fever, with no current vaccines or specific treatments available, highlighting the urgent need for new therapies.
- Researchers focused on the CHIKV nsP2 protease, crucial for viral replication, to identify potential inhibitors using molecular docking and dynamics simulations.
- The study found that trans isomers of certain compounds effectively bind to the protease, revealing important interactions and characteristics that can guide future drug development against CHIKV infections.
Article Synopsis
- The increasing prevalence of Zika and Chikungunya viruses, coupled with a lack of vaccines and antiviral treatments, highlights the need for new therapeutic approaches, particularly using natural compounds.
- Research on the marine brown seaweed Canistrocarpus cervicornis demonstrated its potential antiviral properties, showing that its crude extract and an isolated compound called dolastane both effectively inhibit ZIKV and CHIKV infections in Vero cells.
- Dolastane proved to be significantly more effective than the crude extract and a control antiviral, ribavirin, achieving around 90% reduction in infectivity for CHIKV and 64% for ZIKV, suggesting promising applications for this seaweed-derived compound in future antiviral strategies.
Article Synopsis
- - Mayaro virus (MAYV) is an arthropod-borne virus linked to prolonged joint pain, and currently, there are no effective antiviral drugs or vaccines available for its treatment.
- - Researchers evaluated seven new thieno[2,3-b]pyridine derivatives, finding they could effectively reduce MAYV viral production in non-toxic concentrations in cell cultures.
- - One promising derivative not only inhibited MAYV early in the replication process but also impacted the virus's later stages, indicating its potential as an antiviral treatment for alphaviruses, though further in vivo studies are needed.
Article Synopsis
- - The marine alga Dictyota pfaffii from Northeast Brazil produces dolabellane diterpenes, which could be developed into antiviral drugs targeting HIV-1 by inhibiting reverse transcriptase (RT).
- - Researchers discovered three new diterpenes, dolabelladienols A-C, and confirmed their structures using techniques like NMR and X-ray diffraction.
- - Compounds 1 and 2 showed strong anti-HIV-1 activity (IC50 = 2.9 and 4.1 μM) with low toxicity to tumor cells, suggesting they are promising candidates for anti-HIV therapies.
Background: Chemotherapy for leishmaniasis, a disease caused by Leishmania parasites, is expensive and causes side effects. Furthermore, parasite resistance constitutes an increasing problem, and new drugs against this disease are needed. In this study, we examine the effect of the compound 8,10,18-trihydroxy-2,6-dolabelladiene (Dolabelladienetriol), on Leishmania growth in macrophages.
View Article and Find Full Text PDFAnalysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy.
Francisco das Chagas Abreu da Silveira Bruno de Almeida Lopes Clovis Orlando da Fonseca Thereza Quirico-Santos Izabel Christina Nunes de Palmer Paixão
J Cancer Res Clin Oncol
August 2012
Article Synopsis
- The study investigates the link between the EGF+61A>G genetic polymorphism and the risk of developing malignant gliomas, looking at its effects on EGF levels and response to treatment with intranasal perillyl alcohol.
- Participants included 83 patients with recurrent glioma and 196 cancer-free controls, using techniques like PCR to analyze genetic differences and enzyme immunoassays to measure EGF levels.
- Results indicate that specific genotypes (AA) are more common in glioblastoma patients and correlate with higher EGF levels, while lower EGF levels are associated with better survival and response to treatment.