Publications by authors named "Iyyappan Yuvaraj"
This study aims to investigate the comparative binding pattern of TTHA1873 and its mutants (R55A and R138A) with DNA through molecular docking and molecular dynamics (MD) simulations. The docking results suggests that the Wild type (WT-TTHA1873), R55A, R138A and double mutant R55A/R138A having docking scores of -225.80 kcal/mol, -209.
View Article and Find Full Text PDFAnti-nutrient factors are inherently present in almost all major crops, which impede the absorption of crucial vitamins and minerals upon human consumption. The commonly found anti-nutrients in food crops are saponins, tannins, lectins, and phytates etc. Currently, there is a lack of computational server for identification of proteins that encode for anti-nutritional factors in plants.
View Article and Find Full Text PDFDurum wheat, less immunogenically intolerant than bread wheat, originates from diploid progenitors known for nutritional quality and stress tolerance. Present study involves the analysis of major grain parameters, viz. size, weight, sugar, starch, and protein content of Triticum durum (AABB genome) and its diploid progenitors, Triticum monococcum (AA genome) and Aegilops speltoides (BB genome).
View Article and Find Full Text PDFThermus thermophilus is an extremely thermophilic organism that thrives at a temperature of 65°C. T. thermophilus genome has ~2218 genes, out of which 66% (1482 genes) have been annotated, and the remaining 34% (736 genes) are assigned as hypothetical proteins.
View Article and Find Full Text PDFIn vitro and in silico perspectives to explain anticancer activity of a novel syringic acid analog ((4-(1H-1, 3-benzodiazol-2-yl)-2, 6-dimethoxy phenol)) through apoptosis activation and NFkB inhibition in K562 leukemia cells.
Comput Biol Med
January 2023
Article Synopsis
- Syringic acid (SA) is an effective cancer inhibitor, but its low bioavailability and instability limit its potential, leading to the development of a new analog called SA10.
- In experiments with the K562 cell line, SA10 demonstrated a stronger anticancer effect (IC50 = 50.40 μg/mL) compared to SA (IC50 = 96.92 μg/mL), and showed a two-fold increase in inhibiting NFkB and Bcl-2.
- Molecular docking studies revealed that SA10 binds more effectively to the NFkB protein than SA, suggesting that it could be a promising therapeutic candidate for cancer treatment due to its improved NFkB inhibition.
The entomopathogenic nematode, Heterorhabditis indica, is a popular biocontrol agent of high commercial significance. It possesses tremendous genetic architecture to survive desiccation stress by undergoing anhydrobiosis to increase its lifespan-an attribute exploited in the formulation technology. The comparative transcriptome of unstressed and anhydrobiotic H.
View Article and Find Full Text PDFArticle Synopsis
- Several studies suggest that the release of products like ADP and TDP from the enzyme thymidine mono-phosphate kinase (TMPK) can limit reaction rates.
- This research compared the product release from the human (hTMPK) and Thermus thermophilus (ttTMPK) versions of the enzyme, focusing on how products and substrates interact during this step.
- The findings indicate that while various exit pathways exist for product release, a sequential exit mode is preferred, with hTMPK showing a faster and more directional release than ttTMPK, largely due to different structures in their LID-regions.
- Understanding these differences is crucial for developing targeted inhibitors that can distinguish between eukaryotic and prokaryotic enzymes.
A decade after the concept of Pan-genome was first introduced; research in this field has spread its tentacles to areas such as pathogenesis of diseases, bacterial evolutionary studies and drug resistance. Gene content-based differentiation of virulent and a virulent strains of bacteria and identification of pathogen specific genes is imperative to understand their physiology and gain insights into the mechanism of genome evolution. Subsequently, this will aid in identifying diagnostic targets and in developing and selecting vaccines.
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