Dietary supplementation of Pleurotus tuber regium in rat feed ameliorates metabolic and hematotoxicity induced by carbon tetrachloride.

Pleurotus tuber regium, a wild edible mushroom can reduce free radical-mediated injury and oxidative stress induced by carbon tetrachloride (CCl4) via improvement of antioxidant capacity. This work evaluates the protective effects of this mushroom against the metabolic and hematological toxicity induced by CCl4. Sixty male Sprague Dawley rats were divided into six groups (n = 10).

In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Plants from Rivers State, Niger Delta, Nigeria.

This study evaluated extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of were evaluated for inhibition of acetylcholinesterase (AChE) activity, antioxidant properties, and total phenolic and flavonoid contents using standard procedures. extracts possessed significant and concentration dependent AChE inhibitory activity for methanolic, aqueous, and ethanolic extracts.

Nephroprotective and Antioxidant Effects of King Tuber Oyster Medicinal Mushroom, Pleurotus tuber-regium (Agaricomycetes), on Carbon Tetrachloride-Induced Nephrotoxicity in Male Sprague Dawley Rats.

Chronic kidney disease is a health burden worldwide but particularly in sub-Saharan Africa, with dwindling resources as a result of poor commodity export, devaluation of currencies, and corruption that had decreased the average family income and substantially increased the number of persons living on less than $1.90/day. Natural products are part of the healthcare delivery system in that part of the world.

Protective Effects of on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats.

The high rate of male infertility and the meager resources to manage same in sub Saharan Africa have necessitated the search for cost effective and available alternatives. Mushrooms have been used traditionally in folk medicine and as nutraceuticals. This study has investigated the effect of the wild mushroom on carbon tetrachloride (CCl) deleterious effects on the reproductive system of male rats.