Publications by authors named "Iwona Strycharska-Orczyk"
Article Synopsis
- Melanoma-associated retinopathy (MAR) is linked to malignant melanoma and features autoantibodies against TRPM1, a channel in melanocytes and retinal cells; this study aimed to identify specific regions of the TRPM1 that these autoantibodies target.
- Researchers used patient blood samples to perform tests on modified cells and mouse retinas, successfully determining that MAR autoantibodies recognize a specific part of the TRPM1 gene associated with exons 9 and 10.
- The findings suggest that TRPM1 autoantibodies may be produced in response to abnormal proteins due to an alternative TRPM1 mRNA variant from melanoma, with potential implications for understanding visual symptoms in MAR patients related to TR
Transient receptor potential (TRP) channels constitute a large family of cation permeable ion channels that serve crucial functions in sensory systems by transducing environmental changes into cellular voltage and calcium signals. Within the retina, two closely related members of the melastatin TRP family, TRPM1 and TRPM3, are highly expressed. TRPM1 has been shown to be required for the depolarizing response to light of ON-bipolar cells, but the role of TRPM3 in the retina is unknown.
View Article and Find Full Text PDFTo test the hypothesis that neuroinflammation contributes to dopaminergic neuron death in the MPTP-lesioned mouse, we compared nigrostriatal degeneration in interleukin (IL)-6 (+/+) with IL-6 (-/-) mice. In the absence of IL-6, a single injection of MPTP (30 mg/kg) resulted in significantly greater striatal dopamine depletion than that measured in IL-6 (+/+) mice. The observed dopamine depletion was MPTP dose dependent.
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