Influence of non-irradiated and ultraviolet-A-irradiated N,N-dialanyl protoporphyrin and diarginine diprotoporphyrinate on the neutrophil respiratory burst in vitro.

N,N-Dialanyl protoporphyrin (PP(Ala)2) and diarginine diprotoporphyrinate (PP(Arg)2) are porphyrin photosensitizers that are currently being used in the photodynamic therapy (PDT) of cancer. In the present study, the effects of these agents on the neutrophil respiratory burst in vitro were investigated. In the case of non-stimulated neutrophils, the respiratory burst was significantly increased in the presence of PP(Ala)2 in concentration 5.