Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in cultured cord-blood lymphocytes of newborns of women treated for epilepsy during pregnancy.

Epidemiological data indicate that pregnancies of epileptic women constitute about 1% of all pregnancies. Newborns of mothers exposed to anti-epileptic drugs (AEDs) are at increased risk for major congenital malformations, cognitive impairment and fetal death. Cord-blood lymphocytes of the newborns whose mothers received long-term AEDs therapy during pregnancy were used in this study.

The effect of antiepileptic drugs administered in pregnancy on micronucleus frequency in cord blood lymphocytes.

Objectives: Epidemiological data indicate that the pregnancies of epileptic women constitute about 1% of all pregnancies. A large group of antiepileptic drugs (AEDs) applied in long-term monotherapy or polytherapy produce toxic metabolites as well as free radicals and reactive oxygen species. The aim of this study was to assess the potential genotoxic effect of AED therapy in pregnancy on DNA structure of umbilical cord blood lymphocytes.

[CCAM type II with no clinical symptoms before and after birth--diagnosed in the 21st week of pregnancy and child pediatric observation in the first 3 years of age--a case report].

CCAM is rare congenital malformation of the respiratory tract. Presented case of CCAM type II was diagnosed based on the prenatal examination. In presented case without clinical signs after delivery diagnosis of CCAM type II was established based on prenatal diagnosis.

[The course of neonatal period in neonates of epileptic mothers].

In prospective analysis we compared 211 newborns of women with epilepsy (examined group) and 211 random chose newborns of mothers, without neurological and psychical diseases (control group). Newborns were admitted to ICZMP in 1990-1998 years. In the examined group, the percentage of premature birth, hypotrophia and inborn malformations was higher as compared with the control group.