Publications by authors named "Iwona Kiecka"
Article Synopsis
- Comprehensive genomic sequencing is crucial for managing hematologic malignancies, with tumor:normal sample analysis enhancing differentiation between somatic and germline mutations.
- This study reveals that using cell-free DNA from nail clippings can effectively serve as a normal control, as traditional sources often contain tumor DNA due to the nature of blood cancers.
- However, low-level contamination from tumor DNA occurs more frequently in patients with myeloid diseases and may provide valuable insights into disease evolution and treatment complications like graft-versus-host disease.
Article Synopsis
- Genomic profiling of blood cancers has improved our understanding of the genetic changes that drive these diseases and has helped create better tools for patient treatment planning.*
- Tumor-only sequencing methods often struggle to provide clear information on genetic variants, which can complicate clinical decisions for patient care.*
- The MSK-IMPACT Heme cohort offers a detailed analysis of genetic alterations by comparing tumor and normal DNA, revealing key mutation patterns and enhancing our ability to make precise genetic diagnoses.*
Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined tumor types, coupled with an expanding portfolio of molecularly targeted therapies, demands flexible and comprehensive approaches to profile clinically relevant genes across the full spectrum of cancers. We established a large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which we have compiled tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer and available pathological and clinical annotations.
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